兔肺隐球菌病的CT表现

目的建立标准化不同免疫状态新西兰大白兔肺隐球菌病模型,探讨肺隐球菌病急性期CT表现,并与病理进行对照。方法健康新西兰大白兔40只,随机分为免疫抑制组及免疫正常组。对免疫抑制组注射阿糖胞苷以诱导免疫抑制状态,对全部动物均注射抗生素以预防细菌感染;通过气道注射的方式接种隐球菌菌株,接种后隔天行CT扫描并与病理对照。结果两组病变类型均以实变为主,且多发生于胸膜下,免疫抑制组急性期易出现结节。免疫抑制组病灶多为多发且病程演变过程中病灶范围多有扩大。结论不同免疫状态兔肺隐球菌病急性期病变均以斑片浸润为主,但部分模型肺部亦出现结节、团块改变,提示在急性肺隐球菌病早期即可出现结节、团块样病变。

CT findings of pulmonary cryptococcosis in rabbit models

Objective To explore CT findings of acute phase pulmonary cryptococcosis (PC) by establishing standardized PC rabbit models of different immune status and compare those with pathological results. Methods Forty healthy New Zealand white rabbits were randomly divided into immunosuppressed group and immune normal group. Cytarabine was injected to rabbits in immunosuppressed group, while antibiotics were given to all rabbits to prevent bacterial infection. Cryptococcal strains were inoculated through the airway injection, CT scan was performed the next day after inoculation, and the results were compared with pathology. Results Solid lesions were common, and often occurred in subpleura in both two groups. Nodules were prone to occur in immunosuppressive acute phase in immunosuppressed group. The lesions were multi-typed, and tended to expand in immunosuppression group. Conclusion The acute lesions of rabbit PC of different immune status mainly present as infiltrated plaques, while lung nodules and masses could be found with CT in some models of PC, indicating that nodules and mass-like lesions can occur in acute PC.