帕金森病轻度认知功能障碍:基于体素的全脑灰质形态学研究

目的采用基于体素的形态学测量方法,分析帕金森病(PD)伴轻度认知功能损害(MCI)患者全脑灰质结构的变化。方法利用3.0T MR仪对22例伴MCI的PD患者(PD伴MCI组)、21例认知功能正常的PD患者(单纯PD组)及20名健康对照(NC组)进行T1W扫描。采用SPM8为基础的VBM8工具箱进行数据处理。结果与NC组比较,PD伴MCI组脑灰质萎缩见于双侧额叶、左侧颞叶、双侧枕叶、双侧小脑、左侧后扣带回及左侧海马区域;单纯PD组脑灰质萎缩集中出现于左侧额叶、颞叶。与单纯PD组相比,PD伴MCI组左侧颞中回和海马旁回出现灰质萎缩。结论伴有MCI的PD患者的脑灰质结构改变范围比不伴MCI者更广,提示PD患者认知功能改变存在脑形态结构水平的异常。

Mild cognitive impairment in patients with Parkinson's disease: A voxel-based morphometry analysis of gray matter

Objective To investigate the changes of grey matter in Parkinson's disease (PD) patients with mild cognitive impairment (MCI) using voxel-based morphometry (VBM). Methods Totally 43 PD patients were classified using cognitive testing as PD with normal cognition (single PD, n=21) and PD with MCI (PD-MCI, n=22). And 20 normal controls were enrolled (NC). T1WI were derived using a 3.0T MR scanner. The differences of grey matter volumes were evaluated using VBM. Results Compared with NC, PD-MCI exhibited reduced grey matter volume in bilateral frontal cortex, bilateral cerebellum, the right occipital lobe, as well as in left temporal lobe, posterior cingulate and the hippocampus. Patients with single PD showed limited grey matter atrophy in the left temporal and frontal cortex. Compared with single PD patients, areas of grey matter in the left middle temporal gyrus and parahippocampal reduced in PD-MCI patients. Conclusion PD with MCI is associated with structural neocortical changes in the brain, suggesting that there may exist a gradient of neuropathology structures in PD.