| 马钱子碱体外经皮吸收性质考察 |
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| 引用本文： | 陈军,胡巍,蔡宝昌,胡敏敏. 马钱子碱体外经皮吸收性质考察[J]. 中药材, 2008, 31(3): 445-447 |
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| 作者姓名： | 陈军 胡巍 蔡宝昌 胡敏敏 |
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| 作者单位： | 南京中医药大学药学院,江苏南京,210029 |
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| 摘 要： | 目的考察马钱子碱的体外经皮吸收性质.方法测定马钱子碱的油水分配系数.采用改良的Franz扩散池进行体外经皮吸收实验,选择离体大鼠腹部皮肤为渗透屏障,HPLC法测定马钱子碱的浓度.结果不同温度下马钱子碱的油水分配系数在4.05～5.02之间.0.5和1 mg/ml的马钱子碱游离溶液的经皮吸收速率分别为(1.83±0.50)和(3.74±1.54)μg/cm2·h, 24 h累积透过百分率分别为(51.30±18.51)%和(50.01±12.80)%.结论本研究为马钱子碱经皮吸收制剂设计提供了实验依据.
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| 关 键 词： | 马钱子碱 经皮吸收 油水分配系数 马钱子碱 经皮吸收制剂 性质考察 in vitro Absorption Characteristics 吸收实验 设计 研究 百分率 吸收速率 溶液 温度 结果 碱的浓度 HPLC 渗透屏障 皮肤 腹部 离体大鼠 选择 |
| 文章编号： | 1001-4454(2008)03-0445-03 |
| 修稿时间： | 2007-07-23 |
Study on Transdermal Absorption Characteristics of Brucine in vitro |
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| CHEN Jun,HU Wei,CAI Bao-chang,HU Min-min. Study on Transdermal Absorption Characteristics of Brucine in vitro[J]. Journal of Chinese medicinal materials, 2008, 31(3): 445-447 |
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| Authors: | CHEN Jun HU Wei CAI Bao-chang HU Min-min |
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| Affiliation: | College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China. chenjun75@163.com |
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| Abstract: | OBJECTIVE: To study the transdermal absorption characteristics of brucine in vitro. METHODS: The oil-water partition coefficient of brucine was measured. Drug permeation tests were performed through excised rat skin in improved Franz diffusion cell. Brucine concentration in samples was determined by HPLC. RESULTS: The oil-water partition coefficient of brucine was between 4.05 and 5.02 at different temperatures. The permeation rate of 0.5 and 1 mg/ml brucine solution were (1.83 +/- 0.85) and (3.74 +/- 1.54) microg/cm2 x h, respectively. The cumulative permeation ratio in 24 hours were (51.30 +/- 18.51)% and (50.01 +/- 12. 80)%, respectively. CONCLUSION: The research provides experimental datas for the design of transdermal delivery system of brucine. |
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