| 肾癌患者围手术期CK19mRNA和CK20mRNA的定量分析 |
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| 引用本文： | 齐军,管考鹏,高佳,齐新,李洁,张郁.肾癌患者围手术期CK19mRNA和CK20mRNA的定量分析[J].中国肿瘤,2009,18(11). |
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| 作者姓名： | 齐军 管考鹏 高佳 齐新 李洁 张郁 |
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| 作者单位： | 1. 中国医学科学院肿瘤医院,北京,100021
2. 吉林大学中日联谊医院,吉林,长春,130033 |
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| 基金项目： | Terry Fox基金 |
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| 摘 要： | 目的]探讨肾癌患者围手术期外周血CK19mRNA和CK20mRNA的变化。方法]采用RT-PCR方法检测141例肾癌患者术前血液样本,分析CK19mRNA和CK20mRNA与临床、病理因素的关系;检测103例肾癌患者术前、术中和术后三个时间点的血液标本,并对三组标本进行比较。结果]CK19mRNA、CK20mRNA的表达与患者的性别、年龄和肿瘤大小无关(P均>0.05);术后外周血CK19mRNA的拷贝数(5.68±3.08)高于术前(4.97±3.58),差异有统计学意义(P<0.05);肾癌患者外周血CK20mRNA的拷贝数低于CK19mRNA。结论]检测肾癌患者循环肿瘤细胞CK19mRNA,可反映肿瘤的血源性播散,判断病情。
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| 关 键 词： | CK19mRNA CK20mRNA RT-PCR 肾肿瘤 |
Quantitative Analysis of CK19mRNA and CK20mRNA for Patients with Renal Carcinoma Postoperation |
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| Institution: | QI Jun; GUAN Kao-peng; GAO Jia; et al.; |
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| Abstract: | Purpose] To investigate the variation of serum CK19mRNA and CK20mRNA in patients with renal carcinoma perioperation. Methods] The serum CK19mRNA and CK20mRNA were detected in 141 preoperative patients with renal carcinoma and their correlations with clinicopathological factors were analyzed. The samples at pre-, intra-, and post-operation were detected and compared in 103 cases with renal carcinoma. Results] The serum CK19mRNA and CK20mRNA was not related to agender, age and tumor size (P>0.05). The leve... |
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| Keywords: | CK19mRNA CK20mRNA RT-PCR |
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