Effect of dietary restriction on DNA repair and DNA damage |
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| Affiliation: | 1. Geriatric Research, Education and Clinical Center, Audie L. Murphy Memorial Veterans Hospital, 7400 Merton Minter Blvd., USA;2. Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78284, USA;1. Department of Chemical Science and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy;2. Department of Electronic Engineering, University of Rome Tor Vergata, Via del Politecnico, 00133 Roma, Italy;3. Department of Physics, Chemistry, and Biology, University of Linköping, 58183 Linköping, Sweden;1. NEUROFARBA Department, Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy;2. Institute of Agricultural Biology and Biotechnology, National Research Council, Via Moruzzi, 1, 56124 Pisa, Italy;1. Department of Radiation Oncology (Maastro Lab), GROW School for Oncology & Developmental Biology, Maastricht University Medical Center+, The Netherlands;2. Department of Toxicogenomics, The Netherlands;3. Department of Toxicology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, The Netherlands |
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| Abstract: | Dietary restriction is the only experimental manipulation known to extend lifespan and retard aging in mammals. Therefore, it is a powerful tool for identifying cellular processes that are involved in aging and senescence. Recently, several laboratories have begun to examine the effects of dietary restriction on the integrity of the genome and the ability of cells to repair DNA. In most studies, it was found that the repair of DNA damage, as measured by unscheduled DNA synthesis, was significantly higher in cells isolated from rodents fed calorie-restricted diets compared to cells isolated from rodents fed ad libitum. Dietary restriction also was observed to be associated with a reduction of the levels of certain types of DNA damage; however, preliminary experiments suggest that the effect of dietary restriction on the age-related accumulation of DNA damage depends on the type of DNA damage studied. |
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