Hepatotoxic effects of ethanol and phenformin association in rats |
| |
| Affiliation: | 1. Laboratorio de Metabolismo, Departmento de Investigación, Fácultad de Medicina, Universidad de Guadalajara, Centro Médico, Colonia Independencia, Apartado Postal 1-1185, C.P. 44100, Guadalajara, Jalisco, México;2. Laboratorio de Patologia Experimental, Unidad de Investigación Biomédica de Occidente, Centro Médico de Occidente, Guadalajara, Jalisco, México;3. Division de Neurobiología, Hospital de Oncologia, Centro Médico Nacional, Siglo XXI, Instituto Méxicano del Seguro Social, México, D.F. México. |
| |
| Abstract: | - 1.1. The association of ethanol and phenformin during 6 months in the Sprague-Dawley rat produces an alteration in lactate homeostasis. A basal blood lactate value of 54.13 ± 15.43 mg/dl was found compared to 23.65 ± 7.4 mg/dl in control rats.
- 2.2. Lactic acid levels increased to 28.8 ± 7.42 mg/dl and 22.01 ± 8.08 mg/dl after chronic administration of ethanol or phenformin in Sprague-Dawley rats, respectively. Nevertheless, these were not statistically significant with respect to those of control group.
- 3.3. The total hepatic collagen content after chronic administration of phenformin and ethanol was moderately elevated 7.12 ± 1.85 mg/g of wet tissue, and statistically significant with respect to the control group, 4.77 ± 1.17 mg/g. Collagen content values in phenformin and ethanol rats did not reveal statistically significant differences.
- 4.4. Liver showed histological degenerative changes but not any sign of fibrosis after chronic administration of ethanol and phenformin together.
|
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
