On the potential role of proopiomelanocortin in skin physiology and pathology |
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| Institution: | 1. Terrence Donnelly Heart Centre, St Michael''s Hospital, Toronto, ON, Canada;2. University of Toronto, Toronto, ON, Canada;3. Canadian Heart Research Centre, Toronto, ON, Canada;4. Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK;5. Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States;6. Coronary Care Unit, Concord Hospital, Sydney, Australia;7. DHU FIRE, Université Paris Diderot, AP-HP, Hôpital Bichat, INSERM, U1148 Paris, France |
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| Abstract: | Pro-opiomelanocortin (POMC) is the precursor of ACTH, α-MSH and β-endorphin, neuropeptides with multiple regulatory functions. Both the pituitary gland and peripheral tissues such as mammalian skin are capable of generating POMC-derived neuropeptides. Mammalian skin is also a target for POMC products; their possible roles in skin physiology and pathology are discussed in this communication. |
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