Effects of energy restriction on age-associated changes of DNA methylation in mouse liver |
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| Institution: | 1. Department of Radiation Research, Tohoku University School of Medicine, Sendai 980, Japan;2. Department of Analytical Chemistry I, Kyoto Pharmaceutical University, Kyoto 607, Japan;3. Department of Hygiene, Akita University School of Medicine, Akita 010, Japan;4. Institute for Liver Research, Kansai Medical University, Moriguchi, Osaka 570, Japan;3. Nagahama Institute of Bio-Science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829,;4. Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, and;5. Graduate School of Pharmaceutical Sciences and Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;6. Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;1. Montreal Diabetes Research Center, University of Montreal, QC, Canada;2. CRCHUM, University of Montreal, QC, Canada;3. Department of Medicine, University of Montreal, QC, Canada;4. Department of Biochemistry and Molecular Medicine, University of Montreal, QC, Canada;1. Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou 215006, China;2. Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, China;3. Department of Neurological Surgery, Qinghai Provincial People’s Hospital, Xi’ning 810007, China;4. The Second Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou 215004, China;5. Suzhou Key Laboratory for Molecular Cancer Genetics, Suzhou 215123, China |
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| Abstract: | DNA methylation is known to change with age in several mammalian species. Here we have examined the effect of dietary energy restriction on this age-associated change in liver DNA of C3H/SHN mice. The total 5-methyldeoxycytidine level in the genome decreased slightly soon after energy restriction started. The effect, however, diminished with time and no appreciable difference was detected at middle and old ages. The degree of methylation at the c-myc gene, on the other hand, was not affected by energy restriction at early periods, but the age-dependent alterations at later ages were repressed. This is a new finding to show that DNA methylation is one of the molecular indices of aging affected by energy restriction. It suggests an importance of DNA methylation in the aging process. |
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