Changes of blood gas during endoscopic injection sclerotherapy of esophageal varices |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA;2. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA;3. Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;4. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA |
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| Abstract: | To assess the mechanism of arterial hypoxia after endoscopic injection sclerotherapy (EIS) for esophageal varices, blood gas analysis was carried out in 38 patients with hepatic cirrhosis. The partial pressure of oxygen in arterial blood (Pao2) was decreased more than 15 torr after EIS in 12 (21 %) of 56 sessions of intravariceal injection and in three (16%) of 20 sessions of the paravariceal injection. When blood gas analysis was performed at 30 min after premedication (before EIS) in six patients in whom PaO2 decreased more than 15 torr, the decrease of Pao2 and increase of alveolar-arterial partial pressure of oxygen difference (AaDo2) were identified in all of them already before EIS. These data indicate that arterial hypoxemia after EIS may be the result of not only the direct effect of sclerosant, but also premedication for EIS. |
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