Tetrahydropapaveroline in brain regions of rats after acute ethanol administration |
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| Affiliation: | 1. Département de phytologie, Faculté des sciences de l’agriculture et de l’alimentation Université Laval, Québec, Québec, Canada G1V 0A6;2. Institut des sciences de la forêt tempérée, Université du Québec en Outaouais, 58 rue Principale, Ripon, Québec, Canada J0V 1V0;1. Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran;2. Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran;3. Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran;1. Senior Department of Cardiology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China;2. Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Beijing, China;3. State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China;4. Department of neurology, School of Medicine, South China University of Technology, Guangzhou, China;5. Department of neurology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China;6. Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, China;7. Department of Gastroenterology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China;8. National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China;9. Senior Department of Neurology, The First Medical Center of PLA General Hospital, Beijing, China |
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| Abstract: | Tetrahydropapaveroline (THP), the condensation product of dopamine, and its aldehyde, dopaldehyde, have been detected in brain regions of rats after acute ethanol administration. THP levels were determined in eight brain regions of animals that received ethanol (3.0 g/kg) by intraperitoneal injection 100 or 120 minutes before decapitation. The levels of THP in two brain regions, i.e., the midbrain and striatum, were determined at time intervals ranging from 50 to 120 minutes after ethanol administration. THP was not found in brain regions of untreated animals. However, significant levels of THP were found in pooled midbrains (0.50 pmol/g tissue) and pooled hypothalami (0.20 pmol/g tissue) of animals that received ethanol 120 minutes before decapitation. Most brain regions had detectable levels of THP 100 minutes after the animals received ethanol and the striatum contained the highest concentration of the alkaloid. The concentration of THP in striata tissue of rats at 50, 70, 90, or 100 minutes after ethanol administration were 0.33, 0.38, 0.33, and 0.33 pmol/g tissue, respectively. These results demonstrate that THP can be detected in specific brain regions of the rat after acute ethanol administration. |
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