| 肝细胞肝癌组织MCM2和FAP-1表达及其与癌细胞增殖和凋亡的相关性研究 |
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| 引用本文： | 王晓林,熊枝繁,曹仕琼,冯茂辉.肝细胞肝癌组织MCM2和FAP-1表达及其与癌细胞增殖和凋亡的相关性研究[J].中华肿瘤防治杂志,2011,18(3):205-207. |
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| 作者姓名： | 王晓林 熊枝繁 曹仕琼 冯茂辉 |
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| 作者单位： | 1. 华中科技大学同济医学院附属梨园医院消化内科,湖北,武汉,430077
2. 武汉大学中南医院肿瘤外科,湖北,武汉,430071 |
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| 摘 要： | 目的:研究微型染色体维持蛋白2(MCM2)和Fas相关磷酸酯酶-1(FAP-1)在肝细胞肝癌组织中的表达及其与肝细胞肝癌增殖和凋亡的关系。方法:免疫组化SP法检测40例肝细胞肝癌、15例癌旁肝硬化和10例正常肝组织中MCM2和FAP-1蛋白的表达水平并进行分析。结果:40例肝细胞肝癌组织中29例MCM2表达阳性,28例FAP-1表达阳性,而在癌旁肝硬化和正常肝组织中两者均未见表达。肝细胞肝癌组织中MCM2的表达与患者性别、年龄、肿瘤大小和转移差异无统计学意义,P>0.05;而与分化程度有关,肿瘤分化越低,MCM2阳性率越高,P<0.05。MCM2与FAP-1两者呈正相关,P<0.05。结论:MCM2和FAP-1可能均参与了肝细胞肝癌的发生发展,两者可能相互协同共同促进了癌细胞异常增殖。
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| 关 键 词： | 癌 肝细胞 细胞增殖 细胞凋亡 |
Expressions of MCM2 and FAP-1 and their correlation with proliferation and apoptosis in hepatocellular carcinoma tissues |
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| WANG Xiao-lin,XIONG Zhi-fan,CAO Shi-qiong,FENG Mao-hui.Expressions of MCM2 and FAP-1 and their correlation with proliferation and apoptosis in hepatocellular carcinoma tissues[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(3):205-207. |
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| Authors: | WANG Xiao-lin XIONG Zhi-fan CAO Shi-qiong FENG Mao-hui |
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| Institution: | WANG Xiao-lin1,XIONG Zhi-fan1,CAO Shi-qiong1,FENG Mao-hui2 1.Department of Gastroenterology,Affiliated Liyuan Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077,P.R.China 2.Department of Oncology Surgery,Zhongnan Hospital,Wuhan University,Wuhan 430071,P.R.China |
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| Abstract: | OBJECTIVE: To investigate the relationship between the expressions of MCM2 and FAP-1 with proliferation and apoptosis in hepatocellular carcinoma(HCC).METHODS: The immunohistochemical SP method was used to examine the protein expressions of MCM2 and FAP-1 in HCC tissues(40 cases),hepatic cirrhosis tissues beside tumors(15 cases) and the normal tissues(10 cases).RESULTS: In HCC twenty-nine of 40 cases were found the positive expression of MCM2,and twenty-eight were found the positive expression of FAP-1.But ... |
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| Keywords: | carcinoma hepatocellular cell proliferation apoptosis |
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