| 棉酚对人胃癌细胞SGC-7901的抑制作用 |
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| 引用本文： | 俞耀军,卢明东,孙维建,李丕宏,周香,王飞海,郑志强,游涛. 棉酚对人胃癌细胞SGC-7901的抑制作用[J]. 中国中医急症, 2012, 0(10): 1598-1599 |
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| 作者姓名： | 俞耀军 卢明东 孙维建 李丕宏 周香 王飞海 郑志强 游涛 |
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| 作者单位： | 温州医学院附属第二医院 |
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| 基金项目： | 浙江省温州市科技局基金资助项目(Y20100125) |
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| 摘 要： | 目的研究棉酚(gossypol)对胃癌细胞的增殖抑制作用。方法将不同浓度棉酚与胃癌细胞株SGC-7901作用,采用MTT法检测凋亡情况。结果经棉酚处理后增殖能力降低,细胞显示明显凋亡征象,并随药物浓度增加和作用时间延长而增加。结论棉酚在体外能诱导胃癌细胞SGC-7901发生凋亡,抑制细胞增殖,是一种具有潜在抗肿瘤作用的药物,值得进一步临床试验。
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| 关 键 词： | 胃肿瘤 胃癌细胞株 凋亡 棉酚 |
Effects of Gossypol in Inducing Apoptosis of Human Gastric Cancer Cell Line SGC-7901 |
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| Affiliation: | YU Yao-jun,LU Ming-dong,SUN Wei-jian,et al.The Second Affiliated Hospital of Wenzhou Medical College,Zhejiang,Wenzhou,325003 |
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| Abstract: | Obsjective: To study the mode of action of gossypol on human gastric cancer cell line SGC-7901.Methods: Gastric cancer cell line SGC-7901 treated with various concentrations of gossypol were assessed.MTT assay was used to observe evidence of apoptosis and proliferation.Results: Cell proliferation of Gastric cancer cell line SGC-7901 was decreased and the apoptosis was observed.Apoptotic death is to be dose and time dependent.Conclusions: Cossypol induces apoptosis and decreases cell proliferation in human gastric cancer cell line SGC-7901.It is Suggested that gossypol might be apotential alternative of chemotherapy agent for gastric cancer. |
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| Keywords: | Stomach tumor Stomach cancer cell line Apotosis Gossypol |
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