基于医院信息系统的肝酶升高药品不良反应自动监测系统研究

目的:分析我院常用药品致急性肝功能损害情况。方法:建立医院信息系统(HIS)的肝酶升高药品不良反应(ADR)自动监测系统,对我院2010年12月974例发生肝功能损害的住院患者进行监测,并对其使用的药品进行统计、分析。结果:86例患者在药品使用过程中出现的肝酶升高可能与ADR有关,其中男性51例,女性35例;年龄1～95岁,平均(52.4±25.5)岁;涉及药品40种,抗菌药物占绝大多数,主要是头孢菌素类,其次为心血管系统药、非甾体抗炎药等。结论:该监测系统能及时、准确地发现ADR,监测结果与文献报道相符;特殊人群如老年人和婴幼儿易发生肝功能损伤的ADR;抗菌药物和心血管系统药等出现ADR大多与长期、联合用药有关。

Study on the Automatic Monitoring System for ADR by Elevated Liver Enzymes Based on HIS

OBJECTIVE:To analyze the acute liver injury induced by common drugs in our hospital.METHODS:Automatic monitoring system was established for ADR by elevated liver enzymes based on HIS.974 inpatients with hepatic injury in Dec.2010 were monitored and drugs used were analyzed statistically.RESULTS:It was found that the elevated liver enzymes of 86 inpatients might be related to ADR.There were 51 males and 35 females.The range of age was 1～95 years with mean years old of (52.4±25.5).A total of 40 drugs were involved,the majority were antibiotics,especially cephalosporins,and followed by cardiovascular drugs,non-steroidal anti-inflammatory drugs.CONCLUSION:The monitoring system can accurately and timely find ADR.And the monitoring results are in line with literature reports.Special populations such as the elderly,infants and young children are prone to ADR of liver injury.The elevated liver enzymes caused by antibiotics,cardiovascular drugs and other drugs are mostly related with long-term use and drug combination.