| 促红素对大鼠面神经损伤后促进神经修复的电生理评测分析 |
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| 引用本文： | 傅晓龙,张博,洪青青,王菲,李挺挺,朱倩,周婷婷,朱雨芸. 促红素对大鼠面神经损伤后促进神经修复的电生理评测分析[J]. 四川解剖学杂志, 2010, 18(4): 10-12. DOI: 10.3969/j.issn.1005-1457.2010.003 |
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| 作者姓名： | 傅晓龙 张博 洪青青 王菲 李挺挺 朱倩 周婷婷 朱雨芸 |
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| 作者单位： | 湖州师范学院医学院,湖州313000 |
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| 基金项目： | 浙江省大学生科技创新活动(新苗人才计划)资助项目 |
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| 摘 要： | 目的观测促红素（EPO）治疗大鼠面神经损伤后对面神经电生理的影响。方法 36只SD大鼠随机分成：A组（损伤＋生理盐水）和B组（损伤＋EPO）。B组做面神经挤压损伤后EPO 3000IU/Kg皮下注射每天一次,直至取材。测定各组大鼠面神经的神经电生理和有髓纤维通过率（PR）,观察药物治疗前后大鼠的神经功能的变化。结果经EPO治疗后,B组大鼠面神经的传导速度明显加快,潜伏期减小,波幅升高;EPO组的PR明显优于A组。结论 EPO可改善神经髓鞘功能,有效提高周围神经损伤后的神经传导速度,促进神经的再生与神经功能的恢复。
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| 关 键 词： | 促红素 神经电生理 面神经 损伤 |
Electrophysiological Analysis on Post-injury Facial Nerve of Rat after Using Erythropoietin Treatment to Promote Nerve Convalescence |
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| Fu XiaoLong,Zhang Bo,Hong Qingqing,Wang Fei,Li Tingting,Zhu Qian,Zhou Tingting,Zhu Yuyun. Electrophysiological Analysis on Post-injury Facial Nerve of Rat after Using Erythropoietin Treatment to Promote Nerve Convalescence[J]. Sichuan Journal of Anatomy, 2010, 18(4): 10-12. DOI: 10.3969/j.issn.1005-1457.2010.003 |
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| Authors: | Fu XiaoLong Zhang Bo Hong Qingqing Wang Fei Li Tingting Zhu Qian Zhou Tingting Zhu Yuyun |
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| Affiliation: | Fu XiaoLong Zhang Bo Hong Qingqing Wang Fei Li Tingting Zhu Qian Zhou Tingting Zhu Yuyun(Medical College,Huzhou Teachers College,Huzhou 313000,China) |
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| Abstract: | Objective The aim of this investigatioin was to observe the electrophysiological change of rat post-injury facial nerve after using erythropoietin（EPO） treatment to promote nerve convalescence.Methods Thirty six rats were divided into two groups randomly,namely group A（injury ＋saline group） and group B（injury ＋EPO）.Rats in group B were injected subcutaneously with EPO 3000IU/kg·d after facial nerve constriction injury.The myelinated fibre thruput rate（PR）and neurofunctional change were determined.Results The conductive velocity of facial nerve in group B was step up obviously,with nerve latency grown down,and with amplitude of wave step up.The PR in group B was better than that of group A.Conclusion EPO may improve the function of the facial nerve myelin sheath,elevate nerve conduction velocity of peripheral nerve after injury,and promote nerve regeneration and the neurofunctional recovery. |
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| Keywords: | Eyrthropoietin（EPO） Electrophysiology Facial nerve Injury |
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