Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae |
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| Authors: | Aurélie Renvoisé Pascal Delaunay Elea Blanchouin Isabelle Cannavo Eric Cua Cristina Socolovschi Philippe Parola Didier Raoult |
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| Institution: | 1. Aix Marseille Université, Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198, Inserm 1095, WHO Collaborative Center for Rickettsioses and Other Arthropod Borne Bacterial Diseases, Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille cedex 5, France;2. Service de Parasitologie–Mycologie, Hôpital de l’Archet, Centre Hospitalier Universitaire de Nice and Inserm U895/C3M/Université de Nice-Sophia Antipolis, France;3. Service d’Infectiologie, Hôpital de l’Archet, Centre Hospitalier Universitaire de Nice, France;4. Laboratoire de Virologie, Hôpital de l’Archet, Centre Hospitalier Universitaire de Nice and Inserm U895/C3M/Universite de Nice-Sophia Antipolis, France;1. Department of Genetics, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa;2. Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium;3. Department of Veterinary Tropical Diseases, Faculty Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa;1. Departamento de Patología Animal (Grupo INVESAGA), Facultad deVeterinaria, Universidade de Santiago de Compostela, Lugo, Spain;2. Laboratorio de Vectores y enfermedades transmitidas, Facultad de Veterinaria, Universidad de la República, CENUR Litoral Norte, Salto, Uruguay;3. Department of Parasitology, Faculty of Veterinary Medicine, Miguel Servet, Zaragoza, Spain;1. Vytautas Magnus University, Vileikos 8, LT-44404 Kaunas, Lithuania;2. Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Ko?ice, Slovak Republic;3. W. Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warszawa, Poland;1. Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77845, USA;2. I.I. Schmalhausen Institute of Zoology of National Academy of Sciences of Ukraine, 15 Khmelnytskogo St, Kyiv, 01601, Ukraine;1. Comparative Tropical Medicine and Parasitology, Department of Veterinary Science, Ludwig-Maximilians-Universität München, Munich, Germany;2. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany;3. University Medical Center, Hamburg-Eppendorf, Germany;4. University of Antananarivo, Antananarivo, Madagascar |
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| Abstract: | Here, we report an epidemiological and entomological investigation of a cluster of cases of spotted fever group (SFG) rickettsiosis occurring in southern France. A family of 3 (husband, wife, and their son) presented with symptoms compatible with SFG rickettsiosis. For 2 patients, serum samples presented increased levels of IgM and IgG for SFG Rickettsia. The patients’ home was investigated, and Rhipicephalus sanguineus ticks were collected from the floor from behind the furniture. Of 22 ticks collected, 20 tested positive for Rickettsia. As Rh. sanguineus serves as a vector for both Rickettsia conorii and Ri. massiliae in southern France, all Rh. sanguineus isolates were tested by real-time PCR and conventional PCR to detect the 2 species. Nine ticks tested positive for Ri. conorii subsp. caspia (marking the first documentation of this subspecies in France), 7 tested positive for Ri. massiliae, and 4 tested positive for both rickettsiae. This study is the first report of coinfection of Rh. sanguineus ticks with Ri. conorii and Ri. massiliae in southern France. |
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