| GLI4在结肠癌中的表达及对癌细胞生物学行为的影响 |
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| 引用本文： | 薛小春,陆翠华,田尧. GLI4在结肠癌中的表达及对癌细胞生物学行为的影响[J]. 南华大学学报(医学版), 2022, 0(6): 809-813 |
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| 作者姓名： | 薛小春 陆翠华 田尧 |
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| 作者单位： | 南华大学衡阳医学院 肿瘤研究所,湖南省衡阳市 421001;南华大学衡阳医学院 2018级临床医学系,湖南省衡阳市 421001;南华大学衡阳医学院 2019级临床医学系,湖南省衡阳市 421001 |
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| 基金项目： | 国家自然科学基金项目(81071966);湖南省教育厅科学研究项目(19A442);湖南省大学生创新创业训练计划项目(S202110555312);南华大学大学生创新创业训练计划项目(X202110555532,X202110555535) 作者简介:凌晖,博士,教授,硕士研究生导师,研究方向为非编码RNA与胃癌,E-mail为nhdxlh@126.com。 |
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| 摘 要： | 正常分化的细胞主要依靠线粒体的氧化磷酸化为细胞供能,而大多数肿瘤细胞则依赖有氧糖酵解。各种非编码RNA(ncRNA),如微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA),已被证明在胃癌糖代谢中发挥潜在作用。本文总结了ncRNA在胃癌糖代谢中的作用及机制,以及在胃癌预后及治疗等方面的临床应用前景。
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| 关 键 词： | 胃癌 糖酵解 非编码RNA 微小RNA 长链非编码RNA 环状RNA [ |
| 收稿时间： | 2022-06-12 |
| 修稿时间： | 2022-08-29 |
Expression of GLI4 in colon cancer and its effect on the biological behavior of cancer cells |
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| XUE Xiaochun,LU Cuihu,TIAN Yao. Expression of GLI4 in colon cancer and its effect on the biological behavior of cancer cells[J]. Journal of Nanhua University(Medical Edition), 2022, 0(6): 809-813 |
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| Authors: | XUE Xiaochun LU Cuihu TIAN Yao |
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| Affiliation: | Cancer Research Institute, Hengyang 421001, Hunan, China;2018 Department of Clinical Medicine, Hengyang 421001, Hunan, China; 2019 Department of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China |
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| Abstract: | Normally differentiated cells mainly rely on oxidative phosphorylation of mitochondria for energy supply, while most tumor cells rely on aerobic glycolysis. Various noncoding RNA (ncRNA), including microRNA (miRNA), long-chain noncoding RNA (lncRNA) and circular RNA (circRNA), have been proved to play potential roles in gastric cancer glucose metabolism. This article summarized the role and mechanism of ncRNA involved in glucose metabolism in gastric cancer, and clinical application prospect in the prognosis and treatment of gastric cancer. |
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| Keywords: | gastric cancer glycolysis non-coding RNA miRNA lncRNA circRNA |
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