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Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome |
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| Authors: | Kim Hyung Oh Kim Chong Jin Kim Weon Cho Jin-Man Soeda Tsunenari Takano Masamichi Yan Bryan P Crea Filippo Niccoli Giampaolo Vergallo Rocco Minami Yoshiyasu Higuma Takumi Kimura Shigeki Boeder Niklas Frederik Nef Holger Adriaenssens Tom Kurihara Osamu Thondapu Vikas Russo Michele Yamamoto Erika Sugiyama Tomoyo Lee Hang Kakuta Tsunekazu Yonetsu Taishi Jang Ik-Kyung |
| Institution: | 1.Cardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA ;2.Department of Cardiovascular Medicine, Kyung Hee University, Seoul, South Korea ;3.Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Nara, Japan ;4.Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan ;5.Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Sha Tin, Hong Kong ;6.Department of Cardiovascular and Thoracic Science, Catholic University of the Sacred Heart, Rome, Italy ;7.Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan ;8.Division of Cardiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan ;9.Division of Cardiology, Kameda Medical Center, Kamogawa, Chiba, Japan ;10.Department of Cardiology, University of Giessen, Giessen, Germany ;11.Department of Cardiovascular Medicine, University Hospitals Leuven, Louvain, Belgium ;12.Division of Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA ;13.Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan ;14.Department of Interventional Cardiology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo Ward, Tokyo, 113-8519, Japan ; |
| Abstract: | Postmortem studies reported plaque erosion is frequent in young women. Recent in vivo studies failed to show age and sex differences in the plaque erosion prevalence. The aim of this study was to investigate the prevalence of plaque erosion by age and sex among acute coronary syndromes (ACS) patients. From 1699 ACS patients, 1083 with plaque erosion or rupture were analyzed. Patients were categorized as 5 age groups (≤?50, 51–60, 61–70, 71–80,?≥?81 years). Overall prevalence of plaque erosion was similar between males and females (p?=?0.831). Males age?≤?50 had higher (p?=?0.018) and age 71–80 had lower (p?=?0.006) prevalence of plaque erosion. Females age 61–70 had higher (p?=?0.021) and age 71–80 had lower (p?=?0.045) prevalence of plaque erosion. In advanced age groups (≥?71 years), rupture was the dominant etiology in both sexes. In multivariate analysis of males, age?≤?50 demonstrated a trend to increase (OR 1.418, 95% CI 0.961–2.093, p?=?0.078) the erosion risk. Females age?≤?70 independently increased (OR 2.138, 95% CI 1.249–3.661, p?=?0.006) the risk for erosion. The prevalence of plaque erosion was similar between males and females. Plaque erosion risk was increased in the males age?≤?50 and in the females age?≤?70 among ACS patients. |
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