肿瘤患者肥胖状态下代谢综合征及其组分聚集风险分析

目的:探讨肿瘤患者肥胖状态下代谢综合征（MS）及其组分聚集风险，为肿瘤患者生存期内其他伴随慢病防控管理提供依据。方法:定期健康体检中自报有肿瘤疾病史且体检信息完整者401人，按肥胖状态分为肿瘤非肥胖组和肿瘤肥胖组。肿瘤肥胖组按性别、年龄1∶4随机匹配无肿瘤疾病史且健康体检信息完整者1 501人，其中健康对照即非肿瘤非肥胖组747人，非肿瘤肥胖组754人。采用多因素调整的logistic回归分析肿瘤患者肥胖状态下MS及其组分聚集风险。结果:肿瘤肥胖组和非肿瘤肥胖组MS患病率均高于健康对照组（分别为66.0% vs 56.6% vs 9.2%，P<0.05），也高于肿瘤非肥胖组的6.2%。同时，肿瘤肥胖组和非肿瘤肥胖组中血压升高、血糖升高、甘油三酯升高、高密度脂蛋白降低患病率均高于健康对照组（P<0.05）。多因素调整后，与健康对照组相比，肿瘤肥胖组和非肿瘤肥胖组MS风险仍增加，分别为19.63（95%CI:12.71~30.34）和12.49（95%CI:9.09~17.16）。而且MS组分聚集越多，MS风险越高。结论:肿瘤肥胖患者MS风险增加，其组分聚集越多，MS风险越高。因此，需对肿瘤肥胖患者进行健康管理，有针对性制定防控干预策略，以降低其他伴随慢病发生风险，提高其生存质量。

Association of metabolic syndrome and its components clustered risk in tumor patients with obesity status

Objective:To explore the risk of metabolic syndrome(MS)and its components in tumor obese patients and provide the basis for the prevention,control,and management of other concomitant chronic diseases in their survival time.Methods:There were 401 patients who had a self-reported history of tumor disease during regular physical examination and had complete physical examination information.According to the status of obesity,the tumor patients were divided into tumor non-obese group and tumor obese group.One thousand five hundred and one patients with no tumor history and complete physical examination information were randomly matched with tumor obese group in 1∶4 ratios by age and gender,including 747 persons in the healthy control group(non-tumor non-obese group),and 754 patients in the non-tumor obese group.Multivariate adjusted logistic regression was used to analyze the risk of MS and its components in tumor patients with obesity status.Results:The prevalence of MS both in tumor obese group and non-tumor obese group were higher than that in healthy control group and non-obese tumor group,with 66.0%,56.6%,9.2%,and 6.2%,respectively(all P<0.05).Simultaneously,the prevalence of increased blood pressure,increased blood glucose,increased triglycerides,and decreased HDL-C both in tumor obese group and non-tumor obese group were higher than those in healthy control group(all P<0.05).Compared to the healthy control group,the risk of MS were still increased in tumor obese group and non-tumor obese group after adjusting multiple variables,with OR of 19.63(95%CI:12.71~30.34)and 12.49(95%CI:9.09~17.16),respectively.The more components of MS clustered,the higher risk of MS was.Conclusion:The risk of metabolic syndrome was increased in tumor patients with obesity status.And the more MS components clustered,the higher risk of MS was.Therefore,it is necessary to carry out health management for tumor patients with obesity status,and make specific prevention and control intervention strategies to reduce the risk of other concomitant chronic diseases and to improve their quality of life.