Dynamics of regional distribution of ischemic lesions in middle cerebral artery trunk occlusion relates to collateral circulation |
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| Authors: | Bastian Cheng Amir Golsari Jens Fiehler Michael Rosenkranz Christian Gerloff G?tz Thomalla |
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| Institution: | 1.Klinik und Poliklinik für Neurologie, Kopf- und Neurozentrum, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany;2.Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Diagnostikzentrum Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany |
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| Abstract: | We describe the regional distribution of acute perfusion, diffusion, and final infarct lesions in middle cerebral artery (MCA) trunk occlusion. A total of 31 patients with acute ischemic stroke and MCA trunk occlusion were studied by multiparametric magnetic resonance imaging. Probabilistic maps of lesion distribution were generated. The probability of initial and final infarcts was highest in the central MCA region with decreasing probability toward the periphery where the probability of the tissue at risk of infarction to be saved was highest. The probability of brain regions being involved in acute diffusion lesions and evolving into or escaping from the final infarct relates to the anatomy of arterial blood supply. |
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| Keywords: | magnetic resonance imaging diffusion weighted magnetic resonance imaging perfusion weighted stroke acute tissue plasminogen activator |
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