实体瘤化疗患者植入式静脉输液港治疗的相关感染并发症及危险因素分析

目的:对实体瘤化疗患者行植入式静脉输液港治疗的临床感染并发症及感染率进行分析，探究引起患者相关感染并发症的危险因素。方法:纳入2016年1月至2018年6月在我院介入科接受数字减影血管造影（DSA）引导植入式静脉输液港（IVAP）治疗的实体瘤化疗患者495例进行研究，对患者植入IVAP治疗期的病情进展情况、相关感染并发症及感染率进行回顾性分析，并将可能引起感染并发症的危险因素进行单/多因素分析。结果:495例入组患者中因故拔除IVAP 269例（54.34%），输液港使用时间约为（335±210）d；持续使用IVAP患者226例（45.66%），输液港使用时间约为（368±334）d。39例（7.88%）出现IVAP相关感染，其中早期感染并发症8例（20.51%），晚期感染并发症31例（79.49%）。单因素分析结果显示，穿刺点、化疗方案是显著引起相关感染并发症的初始因素，组间差异具有统计学意义（P＜0.05）。多因素分析结果显示，化疗方案是引起相关感染并发症的危险因素（P＜0.05）。结论:化疗方案是实体瘤化疗患者行植入式静脉输液港治疗期引起相关感染并发症的独立危险因素。

Analysis of infection complications and risk factors related to implantable intravenous port treatment in patients with solid tumor chemotherapy

Objective:To analyse the clinical infection complications and infection rate of solid tumor chemotherapy patients treated with implantable intravenous infusion port and to explore the risk factors of related infection complications in patients.Methods:From January 2016 to June 2018,495 patients with malignant tumor chemotherapy in our hospital accepting digital subtraction angiography(DSA)channel implantable venous infusion port(IVAP)were collected.On the condition of placing IVAP treatment,the progression,related infection complication and infection were analyzed retrospectively,and single and multiple factors analysed the risk factors which may cause infection complications.Results:Among the 495 enrolled patients,269(54.34%)had IVAP removed for some reason,and the duration of use at the infusion port was about(335±210)d.226 patients(45.66%)were treated with continuous IVAP for about(368±334)d at the infusion port.IVAP-related infections were found in 39 cases(7.88%),including 8 cases of early infection complications(20.51%)and 31 cases of late infection complications(79.49%).Univariate analysis showed that the puncture point and chemotherapy regimen were the initial factors that significantly caused the related infection complications,and the difference between the two groups was statistically significant(P<0.05).The results of multivariate analysis showed that the chemotherapy regimen was a disadvantageous factor causing infection-related complications in patients(P<0.05).Conclusion:Chemotherapy regimen are independent risk factors of infection complications in malignant tumor chemotherapy patients treated with implantable intravenous infusion port.