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葛根异黄酮类成分的药理作用研究进展
引用本文:陈凯,魏平慧,史琳. 葛根异黄酮类成分的药理作用研究进展[J]. 现代药物与临床, 2022, 42(12): 2602-2610
作者姓名:陈凯  魏平慧  史琳
作者单位:上饶师范学院, 上饶农业技术创新研究院, 生命科学学院, 江西 上饶 334001;沈阳农业大学 食品学院, 辽宁 沈阳 110866
基金项目:江西省农业农村厅现代农业产业技术体系建设专项(JXARS-16)
摘    要:葛根Pueraria lobata是药食同源中药,具有多种功效。现代药学研究表明异黄酮类是葛根的主要活性成分,已经分离到53个葛根异黄酮化合物,包括葛根素、大豆苷元、大豆苷、葛根素木糖苷、3''-羟基葛根素、染料木素、染料木苷、鹰嘴豆芽素A、芒柄花素、毛蕊异黄酮等,具有解酒护肝、降血糖、调血脂、缓解绝经性骨质疏松、抗肿瘤、心脏保护、抗炎、神经保护、抗氧化等药理作用。对葛根异黄酮类的药理作用进行综述,以期为该类成分的进一步研究和新药研发提供参考。

关 键 词:葛根  异黄酮  药理作用  葛根素  大豆苷元  染料木素  鹰嘴豆芽素A
收稿时间:2022-08-10

Research progress on pharmacological effects of isoflavones from Pueraria lobata
CHEN Kai,WEI Pinghui,SHI Lin. Research progress on pharmacological effects of isoflavones from Pueraria lobata[J]. Drugs & Clinic, 2022, 42(12): 2602-2610
Authors:CHEN Kai  WEI Pinghui  SHI Lin
Affiliation:College of Life Science, Shangrao Normal University, Shangrao Innovation Institute of Agricultural Technology, Shangrao 334001, China; College of Food Science, Shenyang Agriculture University, Shenyang 110866
Abstract:Pueraria lobata is a homology of medicine and food with multiple effects. Modern pharmacological investigations demonstrate that isoflavones are the main active components of P. lobata. And it was reported that 53 isoflavone compounds had been isolated from the root of P. lobata, including puerarin, daidzein, daidzin, puerarin xyloside, 3''-hydroxypuerarin, genistein, genistin, biochanin A, formononetin, calycosin, and so on. They have pharmacological effects such as antialcoholism, liver protection, hypoglycemia, lipid-lowering, menopausal osteoporosis relief, anti-tumor, heart protection, anti-inflammatory, neuroprotection and anti-oxidation. This paper reviews the pharmacological effects of isoflavones from P. lobata, which provides reference for further research and new drug development of this kind of components.
Keywords:Pueraria lobata(Willd.) Ohwi  isoflavones  pharmacological effects  puerarin  daidzein  genistein  biochanin A
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