Her-2/neu基因过表达与胃癌生物学行为的关系研究

目的:了解Her-2/neu基因过表达与胃癌生物学行为的关系。方法:应用免疫组化法检测了具有随访资料的164例胃癌标本的Her-2/neu基因的表达状态。结果:164例胃癌的Her-2/neu基因过表达率为19·51%,其过表达与患者的性别、年龄、肿瘤生长的部位、分化程度、浸润深度、脉管内癌细胞的浸润、UICC分期均无关(P>0·05);仅与胃癌的病理类型密切相关(P<0·05);且Her-2/neu基因过表达与胃癌的预后无关,胃癌的预后仅与胃癌的浸润深度和UICC分期有关。结论:胃癌Her-2/neu基因过表达似与胃癌的病理类型密切相关,预后与肿瘤的浸润深度和UICC分期有关。

Relationship between the overexpression of Her-2/neu gene and biologic behavior of human gastric carcinoma

Objective:To learn the relationship between the overexpression of Her-2/neu gene and biologic behavior of human gastric carcinoma.Methods:Overexpression of Her-2/neu gene in 164 follow-up cases of human gastric carcinoma specimens were detected by immunhistochemistry.Results:The overexpression incidence of Her-2/neu gene in these specimens was 19.51%,the overexpression didn't show a significant correlation to patients'sex age,location of the carcinoma,infiltration depth,differentiated degree,infiltration of carcinoma cells in vessels and UICC staging.(P>0.05),only has a closely relationship with the pathological type of gastric carcinoma.(P<0.05);while overexpression of Her-2/neu gene was irrelated to prognosis of gastric carcinoma.The prognosis was related to the infiltration of carcinoma and the UICC staging.Conclusion:The overexpression of Her-2/neu gene in gastric carcinoma has a closely relationship with the pathologic type of gastric carcinoma,the prognosis of gastric carcinoma was related to the infiltration depth and UICC stsging.