Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family |
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Authors: | Samuelsen Ørjan Castanheira Mariana Walsh Timothy R Spencer James |
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Affiliation: | Ørjan Samuelsen, Mariana Castanheira, Timothy R. Walsh, and James Spencer |
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Abstract: | Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime. |
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