Renin secretion in the earliest stage of goldblatt-type hypertension in rats

Summary Unilateral nephrectomy and constriction of the remaining renal artery in the rat induced a sustained increase of systolic blood pressure, which becomes significant as soon as 90 minutes after operation, and a transient rise in renal venous as well as in peripheral plasma renin activity between 20 and 180 minutes after operation. Unilateral nephrectomyper se, after 90 and 180 minutes, caused a significant fall of the systolic blood pressure, a slight increase of renal venous renin activity after 20 and 45 minutes, and between 3 and 24 hours after operation it was followed by a significant decrease of peripheral plasma renin activity. An increased secretion of renin from the clamped kidney may thus contribute to the initial rise of blood pressure in rats with Goldblatt-type hypertension.Supported by Fonds National Suisse de la Recherche Scientifique, Grant No. 53153.