| 三种类型螯合剂对汞在体内分布和排泄影响 |
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| 引用本文： | 陶正琴,陈振家,严雪铭,徐新华,张建时. 三种类型螯合剂对汞在体内分布和排泄影响[J]. 中国药理学通报, 1991, 0(2) |
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| 作者姓名： | 陶正琴 陈振家 严雪铭 徐新华 张建时 |
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| 作者单位： | 中国科学院上海药物所 上海200031(陶正琴，陈振家，严雪铭，徐新华)，中国科学院上海药物所 上海200031(张建时) |
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| 摘 要： | 小白鼠im~(203)HgCl_2 185kBq/鼠后,立即ip螯合剂,发现在多羧多胺、磷酸、巯基三种类型15个螯合剂中,有7个具有提高排汞的作用,其中以吡哆醇衍生物、半胱氨酸对甲苯磺酸盐及二巯基丁二酸钠(DMS-Na)促排效果较好,分别提高24h尿汞排泄4.6、11.5及22倍,脏器中~(203)Hg含量以DMS-Na组为最低,半胱氨酸对甲苯磺酸盐组次之,但与DMS—Na组相比,相差不显著。
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| 关 键 词： | 螯合剂 ~(203)HgCl_2 排泄 体内分布 |
EFFECT OF THREE TYPES OF CHELATING AGENTS ON EXCRETION AND DISTRIBUTION OF MERCURY |
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| Tao Zhengqin,Chen Zhenjia,Yan Xueming et al. EFFECT OF THREE TYPES OF CHELATING AGENTS ON EXCRETION AND DISTRIBUTION OF MERCURY[J]. Chinese Pharmacological Bulletin, 1991, 0(2) |
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| Authors: | Tao Zhengqin Chen Zhenjia Yan Xueming et al |
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| Abstract: | After the mice had been injected im203HgCl2 185 kBq/mouse, they were injected ip with chelating agents. There were 15 chelating agents of 3 types,of which the effect of eliminate mercury of pyridoxine derivative, benzenesul-fonate cysteine and sodium dimercaptosuccinate ( DMS-Na) were better than the others. The urine excretion of 208Hg was increased and the ratio were 4.6,11.5 and 22 respectively in comparison with the control group.The minimum 203Hg content in organs of mice was in the DMS-Na group,the next was the benzenesulfonate cysteine group,but there no significant difference between these 2groups. |
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| Keywords: | Chelating agent 203HgCl2 Excretion Distribution |
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