c-Jun氨基末端激酶与心肌保护

作为促分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)超家族成员之一的c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)家族是与细胞增殖、分化或凋亡调控密切相关的细胞内信号转导通路.目前越来越多的报道证实了JNK信号途径具有促凋亡和抗凋亡的双重功能,这种双重功能受到细胞类型、刺激物的种类、剂量和持续时间以及胞内其他信号途径的影响.此综述主要探讨JNK在心肌缺血/再灌注(ischemic/reperfusion,I/R)损伤,缺血预处理(ischemic preconditioning,IPC)和缺血后处理中涉入机制及调节作用.

c-Jun N-terminal kinase and myocardial protection

c-Jun N-terminal kinase (JNK) family,one of members of mitogen-activated protein kinase (MAPK) superfamily,is an intraceilular signal transduction pathway involving in cell proliferation,differentiation or apoptosis.More and more studies have identified that JNK signal pathway exerts both pro-apoptosis and anti-apoptosis properties,depending on cell type,nature,doses administered and acting duration of the death stimulus,and the activity of other intracellular signaling pathways.This review presents our current understanding of JNK regulation and its involvement in myocardial ischemic/reperfusion (I/R),ischemic pre-and postconditioning.