侧脑室注射硝普钠对应激性高血压大鼠血压和缰核内神经元电活动的影响 |
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引用本文: | 赵国庆,黄民,崔金娟,王绍.侧脑室注射硝普钠对应激性高血压大鼠血压和缰核内神经元电活动的影响[J].吉林大学学报(医学版),2002,28(4). |
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作者姓名: | 赵国庆 黄民 崔金娟 王绍 |
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摘 要: | 目的 :探讨缰核中的一氧化氮 ( NO)是否参与应激性高血压的形成。方法 :观察由侧脑室注射左旋硝基精氨酸 ( L- NNA)和硝普钠 ( SNP)对血压和缰核内心血管兴奋性神经元电活动的影响。结果 :SNP( 1 0μg)使应激性高血压大鼠血压的下降幅度大于正常鼠 ( P<0 .0 5 ) ;L - NNA( 2 0μg)对应激性高血压大鼠缰核外侧面 ( LHb)心血管兴奋性神经元的兴奋作用低于正常鼠 ,对应激性高血压大鼠缰核内侧面 ( MHb)心血管兴奋性神经元的兴奋作用明显。结论 :缰核内的心血管兴奋性神经元 NO通路调节心血管活动过程 ,缰核内的 NO通路可能参与应激性高血压的形成
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关 键 词: | 缰核 硝普钠 应激性高血压 心血管神经元 |
The effect of injecting sodium nitroprusside into leteral cerebrum ventriculus on blood pressure and unit discharges within the habenula of stress-induced hypertension rats |
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Abstract: | Objective:To probe whether the NO in habenula is closely involved in the pathogenesis of stress induced hypertension.Methods:Inject L NNA and sodium nitroprusside (SNP) into leteral cerebrum ventriculus of normal and stress induced hypertension rats,respectivel, and to examine the changes of blood pressure and the unit discharges within habenula.Results:The depressive effect of SNP (10 μg) on stress induced hypertension rats was larger than that on the normal rats( P <0 05).The excitatory effect of L NNA(20 μg) on cardiovascular neurons LHb of stress induced hypertension rats was lower than that on the normal rats( P <0 05),but on cardiovascular neurons MHb in stress induced hypertension rats was more obvious thant that in normal rats. Conclusion:Cardiovascular neurons from habenula particpate in the blood pressure regulation,and the nitrogen monoxid pathway in habenula may be involved in the pathogenesis of stress induced hypertension. |
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Keywords: | habenula sodium nitropru sside stress induced hypertension cardiovascular neuron |
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