小间隙桥接法和神经外膜吻合法修复周围神经断裂的实验研究

目的：探讨小间隙桥接法和神经外膜吻合法修复周围神经断裂的效果。方法：通过动物实验，对60只SD大鼠的一侧坐骨神经采用小间隙静脉桥接法吻合（实验组），另一侧用采用神经外膜吻合（对照组），观察神经修复效果。结果：实验组大鼠恢复自主活动快（40 d）；显微镜下观察，神经正常生长，神经干完整，神经传导速度快；组织学观察，小间隙部结缔组织增生明显减少，神经纤维排列有序；透射电镜观察，间隙远端再生神经与正常神经无差异。而对照组无上述变化。结论：小间隙静脉桥接法可最大限度地修复断裂的神经，其效果明显优于神经外膜吻合法。

Experimental study on small gaps bridging and epineurial suture in repairing rupture of peripheral nerves

Objective To discuss the curative effects of small gaps bridging and epineurial suture in repairing the rupture of peripheral nerves.Methods One side of sciatic nerve of 60 SD rats was treated by small gaps briding(experimental group),another side was treated by epineurial suture(control group).Results In experimental group,the recovery time of autonomous motion(40 d) was shorter;nerves growed normally,nerve trunk was intact,the nerve conduction velocity was fast when observed under microscope;the proliferation of connective tissues in small gaps decreased markedly,nerve fiber arranged regularly when observed with histological method;there was no difference between regenerative nerves in the distal gaps and normal nerves when observed under transmission electron microscope.And there were no changes mentioned above in control group.Conclusion This method of small gasps bridging can repair the rupture of nerves in great degree,and its curative effect is superior to that of epineurinal suture.