| CXCL12／CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展 |
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| 引用本文： | 杨晨,姚阳. CXCL12／CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展[J]. 陕西肿瘤医学, 2009, 17(8): 1599-1601 |
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| 作者姓名： | 杨晨 姚阳 |
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| 作者单位： | 上海市交通大学附属第六人民医院肿瘤内科,上海200233 |
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| 基金项目： | 上海市市级医学慢性病综合防治项目资助（SHDC12007304） |
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| 摘 要： | 研究发现趋化因子CXCL12（Stromal—derived factor-1，SDF-1）和受体CXCR4[chemokine（C—X—Cmotif）receptor4]广泛表达于组织和器官上，相关的研究发现其与前列腺癌细胞的黏附、侵袭、增殖和生存有关，并认为其在前列腺癌骨转移的发生中发挥重要作用。通过阐明CXCL12／CXCR4生物学轴和前列腺癌骨转移之间的关系，从而寻找有助于疾病治疗的新途径。
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| 关 键 词： | CXCL12 CXCR4 前列腺癌 骨转移 |
Advance in the research of the mechanism of CXCL12/CXCR4 axis induced osseous metastasis of prostate cancer |
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| YANG Chen,YAO Yang. Advance in the research of the mechanism of CXCL12/CXCR4 axis induced osseous metastasis of prostate cancer[J]. Shaanxi Oncology Medicine, 2009, 17(8): 1599-1601 |
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| Authors: | YANG Chen YAO Yang |
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| Affiliation: | ( Department of Oncology,Shanghai Sixth People＇s Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233, China.) |
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| Abstract: | CXCL12 （ stromal - derived factor - 1, SDF - 1 ） and its receptor CXCR4 （ chemokine （ C - X - C motif） receptor 4） were demonstrated to be widely expressed in a broad array of tissues and organs. Recent studies suggested that CXCL12/CXCR4 axis was related to the adhesion, invasion, proliferation and survival of prostate cancer cells, and played an important role in bone metastasis. Elucidating the relationship between the CXCL12/CXCR4 axis and the development of bone lesion of prostate cancer is helpful to find a new way to treat the disease. |
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| Keywords: | CXCL12 CXCR4 Prostate cancer Bone metastasis |
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