| THE VARIANCE OF ESTERASE D IN RETINOBLASTOMA |
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| 作者姓名： | 王和 丘建春 李世绩 周宏远 高秀坤 方谦逊 罗成仁 李安仁 |
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| 作者单位： | Institute of Oncology，West China University of Medical Sciences，Institute of Oncology，West China University of Medical Sciences，Institute of Oncology，West China University of Medical Sciences，Institute of Oncology，West China University of Medical Sciences，Institute of Oncology，West China University of Medical Sciences，Department of Ophthalmology，West China University of Medical Sciences，Department of Ophthalmology，West China University of Medical Sciences，Department of Ophthalmology，West China University of Medical Sciences |
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| 摘 要： | Esterase D (EsD) was evaluated in 20 patients with retinoblastoma (RB). The EsD activity of the hemolysates of three unilateral cases was normal and the EsD phenotypes of their tumor cells were zero. In another three cases, including one patient with bilateral RB, the EsD was heterozygous, but the tumor cells expressed enzyme from only one of the two EsD alleles. These results provided fresh evidence for Comings' theory of tumorigenesis in which the production of sporadic nonhereditary RB has been explained.
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