碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4在胃癌中的表达及其意义

目的：探讨碱性成纤维细胞生长因子(basic fibroblast growth factor，bFGF)和成纤维细胞生长因子受体-4(fibroblast growth factor receptor-4，FGFR-4)在胃癌组织中的表达及其意义。方法：应用免疫组化方法，检测81例胃癌及其癌旁组织中碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4的表达。结果：11例癌旁正常胃粘膜上皮有1例碱性成纤维细胞生长因子(9．1％)，2例成纤维细胞生长因子受体-4(18．2％)染色阳性；5例癌旁不典型增生中碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4染色阳性各2例(40％)；4例癌旁肠化碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4染色阳性分别有2例(50．0％)和1例(25．0％)；81例癌组织碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4染色阳性分别为72例(88．89％)和74例(91．36％)；癌组织碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4染色阳性率明显高于癌旁肠化及不典型增生(P＜0．01)；胃癌组织中碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4表达的水平与患者肿瘤部位、组织学类型及分化程度无关(P＞0．05)；碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4染色呈明显相关(P＜0．01)。结论：碱性成纤维细胞生长因子和成纤维细胞生长因子受体-4在胃癌组织中表达明显增高可能与肿瘤的发生发展有关。

Expression and Implication of Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptor-4 in Gastric Cancer

Objective:To investigate the expression, location and respective implication of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-4 (FGFR-4) in human gastric carcinoma. Methods:The expression levels of bFGF and FGFR-4 in 81 gastric carcinoma tissues and pericancer tissues, including atypical hyperplasia, metaplasia and normal tissues, were determined by means of enzyme immunohistochemical method. Results:The positive rates of bFGF and FGFR-4 in carcinoma tissues were 88.89% and 91.36% respectively, significantly higher than that in the metaplasia (50.0% and 25.0%, respectively) and in atypical hyperplasia (40.0% each) of the pericancer tissues (P<0.01). No relationship was found between the histological subtypes and region of gastric cancer and expressions of bFGF and FGFR-4 (P>0.05). The positive relation was found between the expression of bFGF and FGFR-4 in carcerous tissues (P<0.01). Conclusion:The over-expressions of bFGF and FGFR-4 appear in the gastric carcinoma tissues and might be involved in the invasiveness and metastasis of gastric carcinoma.