| 壳聚糖的毒性研究 |
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| 引用本文： | 程东,韩晓英,冯宁,张天亮,李慧. 壳聚糖的毒性研究[J]. 现代预防医学, 2006, 33(2): 162-164 |
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| 作者姓名： | 程东 韩晓英 冯宁 张天亮 李慧 |
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| 作者单位： | 1. 山东省疾病预防控制中心,济南,250014
2. 山东大学毒理学研究所 |
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| 摘 要： | 目的：研究壳聚糖的毒性。方法：小鼠急性毒性试验、AmeS试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、大鼠30d喂养试验。结果：壳聚糖属实际无毒物质；Ames试验、微核试验和精子畸形试验结果均为阴性；大鼠30d喂养试验结果显示该样品30d喂养对大鼠各项观察指标未见毒性作用。结论：在本次实验条件下，壳聚糖为无毒物质，未显示有遗传毒性和亚急性毒性作用。
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| 关 键 词： | 壳聚糖 急性毒性试验 遗传毒性试验 大鼠30d喂养试验 |
| 文章编号： | 1003-8507（2006）02-0162-03 |
| 收稿时间： | 2005-07-14 |
| 修稿时间： | 2005-07-14 |
STUDY ON TOXICITY OF CHITOSAN |
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| CHENG Dong, HAN Xiao-ying, FENG Ning,et al.. STUDY ON TOXICITY OF CHITOSAN[J]. Modern Preventive Medicine, 2006, 33(2): 162-164 |
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| Authors: | CHENG Dong HAN Xiao-ying FENG Ning et al. |
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| Affiliation: | Department of Toxicology,Shandong Center for Disease Control and Prevention, Jinan, 250014. |
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| Abstract: | Objective:To study the toxicity of chitosan.Methods:Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice,thirty days feeding study were done.Results:Chitosan was a substance with no toxicity.The results of genetic toxicity test were all negative,including Ames test,micronucleus test and sperm shape abnormality test.The results of thirty days feeding study was also negative.Conclusion:Chitosan is a substance with no toxicity and have no genetic toxicity and subacute toxicity under the condition of this test. |
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| Keywords: | Chitosan Acute toxicity test Genetic toxicity Thirty days feeding study |
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