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| 实验性海洛因成瘾所致肌病与肾损害 | |
| 引用本文： | 李桢,徐汝昌,赵永和,杨真,王旭,韩晓华,希尔顿.实验性海洛因成瘾所致肌病与肾损害[J].昆明医学院学报,2004,25(4):1-5. |
| 作者姓名： | 李桢 徐汝昌 赵永和 杨真 王旭 韩晓华 希尔顿 |
| 作者单位： | 1. 昆明医学院法医学院,昆明,650031 2. 昆明医学院第二附属医院,昆明,650101 3. 昆明市公安局盘龙公安分局戒毒所,昆明,650021 4. 昆明市公安局盘龙公安分局,昆明,650021 5. 新南威尔斯州法医研究所,澳大利亚,悉尼,2037 |
| 基金项目： | 云南省自然科学基金资助项目 (97CO5 7M ) |
| 摘 要： | 目的：通过对海洛因成瘾实验动物进行组织学观察研究，揭示海洛因成瘾与由之所致肾损害及横纹肌损害之间的关系．方法：采用海洛因腹腔注射方法建立不同时期成瘾动物模型，并对实验动物横纹肌及肾组织进行免疫组化及电镜观察．结果：(1)横纹肌和肾组织有不同程度损伤，部分动物肾组织中检出肌红蛋白成分；(2)肾脏病理组织学改变与海洛因成瘾时间具有一定的关系．结论：海洛因依赖对横纹肌和肾组织具有一定的损害作用。 |
| 关 键 词： | 海洛因成瘾 肾损害 肾组织 横纹肌 肌病 实验性 肾脏病理 实验动物 不同时期 电镜观察 |
Experimental Myopathy and Renal Damage Associated with Heroin |
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| Abstract.Experimental Myopathy and Renal Damage Associated with Heroin[J].Journal of Kunming Medical College,2004,25(4):1-5. | |
| Authors: | Abstract |
| Abstract: | The effects of heroin on rat striped muscle and kidney were studied. Heroin was injected intraperitoneally. The quadriceps, the myocardium and the renal tissue were studied using histological technique and electron microscopic technique. The kidney was also studied by immunohistochemical technique. Morphological changes were detected at different time intervals. The results showed the myotoxic effect of heroin on striped muscles and kidney. Myoglobin was demonstrated in kidney. The pathogenesis of kidney change is discussed. |
| Keywords: | Rhabdomyolysis Kidney Myoglobin Electron microscopy Immunohistochemistry Heroin |
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