Congenital cytomegalovirus infection and Wiskott-Aldrich syndrome successfully treated with unrelated cord blood transplantation |
| |
| Authors: | Almagor Yotam Revel-Vilk Shoshana Averbuch Diana Mechoulam Hadas Engelhard Dan Resnick Igor B Weintraub Michael Stepensky Polina |
| |
| Affiliation: | Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel. |
| |
| Abstract: | We report a successful umbilical cord blood transplantation (UCBT) in an 8-month male with Wiskott-Aldrich syndrome (WAS) and congenital cytomegalovirus (CMV) infection. The child presented at 3 months of age with symptomatic thrombocytopenia and CMV infection. Despite appropriate antiviral treatment no rise in the platelet count was observed. Genetic analysis confirmed the diagnosis of WAS. The clinical course was complicated by severe CMV retinitis with bilateral retinal hemorrhages and renal vasculitis. He underwent unrelated UCBT resulting in a rapid resolution of autoimmunity and thrombocytopenia. |
| |
| Keywords: | cord blood transplantation cytomegalovirus infection Wiskott–Aldrich syndrome |
| 本文献已被 PubMed 等数据库收录！ |
