基于功能磁共振成像技术的针刺机制研究现状分析

以"针刺""功能磁共振成像""Acupuncture""fMRI""Magnetic Resonance Imaging"等为检索词,检索2003年1月至2014年12月CNKI(中国知网)、PubMed数据库,最终纳入253篇运用功能性磁共振成像(fMRI)技术研究针刺机制的文献。运用文献计量学方法分析发现:近10年内该类研究数量总体呈增长趋势;研究的受试对象以健康人为主,涉及病种以神经系统疾病为主;研究内容以穴位特异性最多,而对穴位配伍规律的研究较少。结果提示,以fMRI为手段的针刺脑功能成像研究在研究内容上相对单一,试验设计和质量控制有待进一步提升。

Current Status of Researches on Brain-imaging Responses of Acupuncture Stimulation Based on Functional Magnetic Resonance Imaging

Using functional magnetic resonance imaging(fMRI)to investigate the underlying mechanisms of acupuncture therapy attracts an increasing attention nowadays.In the present article,the authors make a brief analysis on the progresses of researches about the intra-brain responses of acupuncture stimulation following collecting original research papers with key words of"acupuncture","fMRI"and "magnetic resonance imaging"in PubMed and CNKI databases from January 2003 to December2014.As a result,a total of 253 original research articles were collected.We found that:1)in the past 10 years,the amount of fMRI studies on acupuncture is growing;2)most of these studies(183)are conducted in healthy subjects,and fewer studies(44)conducted in patients with problems of neurology,psychonosology,gastroenterology,circulation system,pediatrics,myopia and dermatology,or with pain;3)a larger population of studies are designed to reveal the specificity of responses of acupuncture point stimulation,and fewer focus on analyzing the regularities of acupuncture points combination.The authors suggest that the coming acupuncture-neuroimaging studies need to expand the research ranges or contents,and improve experimental designs,data analysis and quality control(for example,reducing differences of baseline data,age span,psychological state,etc.,and increasing sample size,etc).