基于细胞因子的针刺治疗类风湿关节炎的镇痛、抗炎机制研究进展

细胞因子与类风湿关节炎(RA)的发生、发展密切相关。针刺可通过提高抗炎细胞因子含量、降低促炎细胞因子含量,调整Th 1/Th 2平衡,从而达到抗炎、镇痛的作用,充分体现了针刺双向调节的作用特点。目前的研究也存在一些问题,如相关细胞因子研究的深度、广度和新度不够;研究水平不高,各研究结果之间存在一定矛盾;研究缺乏中医整体观等。因此,结合目前细胞因子与RA、神经-内分泌-免疫网络作用机制的最新研究进展,采用目前高通量的细胞因子检测手段,将针刺治疗后机体多靶点部位(关节局部、外周血液、中枢)的细胞因子相结合,整体、动态、网络地研究针刺对RA细胞因子的影响,有望取得新进展。

Development of Researches on Cytokine Mechanisms in Analgesia and Anti-inflammation in Acupuncture Therapy for Rheumatoid Arthritis

Cytokines are closely related to the occurrence and development of rheumatoid arthritis(RA).Acupuncture exerts anti-inflammatory and analgesic effects via elevating anti-inflammatory cytokine level and reducing pro-inflammatory cytokine level and regulating Th 1/Th 2balance,which reflects the dual directional regulatory effect of acupuncture.However,problems exist in the current researches,such as inadequate depth,limited breadth and not so up-to-date research focus.The mediocre research level and the phenomena of some contradictory results among studies also need being concerned.Therefore,progress may be attained if a holistic,dynamic and networked study is conducted on the influence of acupuncture on cytokines by combining the latest progress in the mechanisms of network of cytokines and neuroendocrine immune network,and high throughput cytokine capture assay.In this way,the mechanism of cytokines in multi-targets(such as local joints,peripheral blood circulation,central nervous system)involving the effects of acupuncture in improving RA will be known more.