跑台运动训练对2型糖尿病大鼠股骨骨密度的影响

目的研究不同强度跑台运动训练对2型糖尿病大鼠股骨骨密度的影响，为探讨有氧运动对2型糖尿病骨并发症的防治提供实验依据。方法选取52只8周龄健康雄性SD大鼠，随机分成正常对照组10只和2型糖尿病造模组42只。造模组大鼠在高糖、高脂和高能量饲料喂养4周后，一次性腹腔注射链脲佐菌素30mg／kg，以建立2型糖尿病大鼠模型。取30只造模成功的2型糖尿病大鼠，随机分成糖尿病对照组、小强度运动组和中强度运动组，每组10只。运动组实施8周运动方案。采用固体物理密度仪测定实验大鼠股骨骨密度。结果与正常对照组相比，糖尿病对照组和小强度运动组的股骨骨密度显著降低（P〈0．05），中强度运动组的股骨骨密度显著升高（P〈0．05）；与糖尿病对照组、小强度运动组相比，中强度运动组股骨骨密度显著升高（P〈0．01）。结论①2型糖尿病大鼠股骨骨密度低于正常，为骨质疏松症高危群体；②跑台运动训练对2型糖尿病大鼠股骨骨密度的影响与运动强度有关。

Effects of treadmill exercise training on femur bone mineral density in rat model of type 2 diabetes

Objective To investigate the effects of different intensity of treadmill exercise training on femur bone mineral density （BMD） in rat model of type 2 diabetes and to provide experimental basis of aerobic exercise for the pre- vention and treatment of type 2 diabetes. Methods 52 sanitized 8 - month - old male SD rats were randomized into the control group （n = 10） and type 2 diabetes model group （n =42 ）. The rats of type 2 diabetes model group were fed by food with high glucose, fat and energy for 4 weeks, before streptozotocin at a does of 30 mg/kg was given by a bout of in- traperitoneal injection to establish rat model of type 2 diabetes. 30 successful type 2 diabetes model rats were allocated at random into 3 groups： diabetes control, lower and moderate intensity exercise groups （n = 10 each）. The treadmill train- ing protocol of exercise group was in 8 weeks. BMD was measured by using solid physical density instruments. Results Compared with the control group, the femoral BMD significantly decreased in both diabetic control group and diabetic low- er - intensity exercise group （ P 〈 0.05 ）, and significantly increased in diabetic moderate - intensity exercise group （ P 〈 O. 05）. Compared with the diabetic control group, femoral BMD significantly increased in diabetic moderate - intensity exercise group （P 〈 0. O1 ）. Compared with lower intensity group, femur BMD significantly increased in the moderate in- tensity exercise group （ P 〈 0.01 ）. Conclusion （1） The femoral BMD of type 2 diabetic model rats was lower than that in the normal control rats, which suggests that the model rats with type 2 diabetes are at a high risk for osteoporosis. （2） The effects of treadmill exercise training on femoral BMD in type 2 diabetes model rats was related to exercise intensity.