| 从炎症调节因子到肿瘤抑制因子——A20的特点及其在淋巴细胞肿瘤发生中的作用 |
| |
| 引用本文： | 李扬秋,杨力建,陈少华,李箔.从炎症调节因子到肿瘤抑制因子——A20的特点及其在淋巴细胞肿瘤发生中的作用[J].循证医学,2011,11(1):54-59. |
| |
| 作者姓名： | 李扬秋 杨力建 陈少华 李箔 |
| |
| 作者单位： | 暨南大学 a. 医学院血液病研究所, b. 再生医学教育部重点实验室, 广州 510632 |
| |
| 基金项目： | 国家自然科学基金，中央高校基本科研业务费专项资金资助项目 |
| |
| 摘 要： | A20是炎症信号传导的中心调节因子-NF-κB抑制因子，而近年研究发现A20更重要的功能是作为一个肿瘤抑制因子，其缺失在淋巴细胞肿瘤的发生中有重要的作用。综述近年所报道的A20生物学功能、分子机制及其在淋巴细胞肿瘤中调节作用的研究进展。
|
| 关 键 词： | 淋巴细胞肿瘤 A20 肿瘤抑制因子 |
From Inflammation Regulator to Tumor Suppressor-The Feature of A20 and Its Role in the Initiation of Lymphocytic Malignancy |
| |
| LI Yang-qiu,YANG Li-jian,CHEN Shao-hua,LI Bo.From Inflammation Regulator to Tumor Suppressor-The Feature of A20 and Its Role in the Initiation of Lymphocytic Malignancy[J].The Journal of Evidence-Based Medicine,2011,11(1):54-59. |
| |
| Authors: | LI Yang-qiu YANG Li-jian CHEN Shao-hua LI Bo |
| |
| Institution: | a. Institute of Hematology of Medical College, b. Key Laboratory for Regenerative Medicine of Ministry of Education, Ji’nan University, Guangzhou 510632, China |
| |
| Abstract: | A20 was originally identified as a key regulator of inflammation signalling pathways, a NF-KB inhibitor. Recently, A20 has also been proposed to function as a tumor suppressor. Lacking A20 is involved in tumorigenesis in several human B-cell lymphomas. In this review, current knowledge concerning the feature of A20 biological activities, as well as the underlying molecular mechanisms, and the regulating role of A20 in lymphocytic malignancies is summarized. |
| |
| Keywords: | A20 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《循证医学》浏览原始摘要信息 |
| 点击此处可从《循证医学》下载免费的PDF全文 |
