| 丹皮酚对大鼠心肌缺血再灌注损伤保护中HMGBl表达的影响 |
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| 引用本文： | 翟昌林,黎莉,张运. 丹皮酚对大鼠心肌缺血再灌注损伤保护中HMGBl表达的影响[J]. 中医药学刊, 2012, 0(10): 2284-2286,I0006 |
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| 作者姓名： | 翟昌林 黎莉 张运 |
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| 作者单位： | [1]山东大学齐鲁医院卫生部心血管重构与功能研究重点实验室,山东济南250012 [2]浙江省桐乡市第一人民医院,浙江桐乡314500 |
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| 基金项目： | 嘉兴市科技计划项目（2010AYll67）;桐乡市重点科技计划项目（201003108） |
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| 摘 要： | 目的：探讨丹皮酚（paeonol，Pae）对大鼠心肌缺血再灌注损伤保护中HMGBl表达的影响。方法：清洁sD大鼠40只随机分为4组（／2=10）：假手术组（Sham组）、缺血再灌注组（I／R组）、丹皮酚低剂量组（PaeLD组）及丹皮酚高剂量组（PaeHD组）。建立大鼠心肌缺血再灌注模型。TTC染色法检测大鼠梗死心肌体积，Tunnel法检测心肌缺血坏死区细胞凋亡；免疫印迹检测缺血坏死组织HMGBl的表达。结果：PaeLD及PaeHD组与lfR组相比，心肌梗死体积减小，凋亡细胞减少；心肌组织HMGBl水平明显减少。其中PaeHD组更明显。结论：丹皮酚能够减轻大鼠心肌缺血再灌注损伤，其机制可能与减轻大鼠HMGBl表达有关。
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| 关 键 词： | 丹皮酚 高迁移率族蛋白1 缺血再灌注损伤 |
Protective Effects of Paeonol on Myoardial Ischemia and Its Influence on the Expression of HMGB] in Rats |
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| ZHAI Chang-lin,LI Li,ZHANG Yun. Protective Effects of Paeonol on Myoardial Ischemia and Its Influence on the Expression of HMGB] in Rats[J]. Study Journal of Traditional Chinese Medicine, 2012, 0(10): 2284-2286,I0006 |
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| Authors: | ZHAI Chang-lin LI Li ZHANG Yun |
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| Affiliation: | 1. Cardiovascular Remodeling and Function Research Laboratory, Shandong University, Jittmt 250012, Shandong, China ; 2. Tongxiang First People Hospital, Tongxiang 314500, Zhejiang, China) |
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| Abstract: | Objective：To investigate the paeonol~ influence on HMGB1 expression of myocardial ischemia reperfusionin rats. Methods ：40 SD rats were randomly divided into 4 groups：sham operation group （Sham group）, ischemia reperf usion group（ I/R group） ,low dose of paeonol group（ PaeLD group）and high dose of paeonol group（ PaeHD group）. Rat myocardial infarction volume was detected by TI＇C staining method, myocardial ischemia necrosis apoptosis by Tunnel method,while HMGB1 expression in ischemia necrosis tissue by immunoblotting. Results：Compared with LCR group, the volume of myocardial infarction,apoptotic cells number and serum HMGB1 levels in PaeLD and PaeHD group were de creased significantly（ P 〈 0.01 ） while the PaeHD group was more obvious. Conclusion ： Paeonol can reduce rats myocardial ischemic reperfusion injury, the mechanism may be related to the decrease of HMGB1 mediated inflammatory response in myocardial ischemia reperfusion. |
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| Keywords: | paeonol high mobility group box 1 ischemia reperfusion injury |
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