多原发性恶性肿瘤的远期疗效和预后因素

本文报告12年间收治的多原发性恶性肿瘤(MPC)105例,均经病理证实.占同期收治恶性肿瘤的1.03％.经手术及/或放疗、化疗后,第一癌治疗后5、10、15、20和25年生存率分别为73.5、60.6、38.3、21.2和8.0％.最后一癌治疗后的3、5、10、15和20年生存率分别为50.7、37.3、23.3、6.1和2.1％.结果说明,如正确诊治,MPC患者的预后并不很差.影响MPC预后的因素中,同时性比异时性MPC的生存率明显为低;老年比青年发病者的生存率差(P<0.01).本组未发现性别、间隔时间、发病部位及病理类型等对其预后有明显影响.

Multiple Primary Cancer-Long Term Results of Therapy and Prognosis Factor

From September 1977 to August 1989,10178 patients with malignant tumors were treated in our hospital. One hundred and five(l. 03%) of them were pathologically proven having inflicted by multiple primaries. Treatment given consisted of various combination of surgery,radiotherapy and chemotherapy. The 5-,10-, 15-,20-and 25- year survival rates following the treatment of the first malignancy were 73. 5% ,60. 0% ,38. 3% , 21. 2% and 8. 0% respectively. The 3-,5-,10-,15-, and 20-year survival rates following the treatment of the last cancers were 50. 7%, 37. 3%,23. 3%,6. 1% and 2. 1 % respectively. The results showed that the outcome of multiple primary cancer(MPC)were not that poor if they were timely and properly treated. Synchronousness of MPC was obviously a more unfavorable factor than asynchronism. Survival rates of younger patients were better than that of older ones. The following factors didn' t affect the prognosis of MPC,they are sex,interval,site,and pathologic type.