原发性肝癌姑息切除术后插管化疗的临床研究

本文对38例原发性肝癌姑息性切除术后,经肝动脉、门静脉插管化疗与38例相同病期仅作姑息性切除的肝癌患者进行配对分析,结果显示插管化疗组AFP转阴率及术后1年生存率均显著高于未插管组,分别为84.8％与 61.3％,55.3％与21.1％(P<0.05).而AFP术后3个月转阳率插管组低于未插管组,分别为50％与74.5％(P<0.05).提示对无法行根除性切除的肝癌患者,在作姑息切除术的同时,行肝动脉、门静脉插管化疗,对提高术后生存率有确切疗效.

A Clinical Study of Regional Infusion Chemotherapy after Palliative Resection of Primary Liver Cancer

Thirty eight cases of primary liver cancer were treated with regional infusion chemotherapy via hepatic artery and protal vein in the wake of palliative resection of the tumor. As compared with 38 similar patients who received only palliative resection it was shown that the fall of AFP level to normal and 1-year survival rate were 84. 8% ,61. 3% in the former group and 55.3%,21.1%inthe latter (P<0. 05). In patient in whom the AFP level rose again in 3 months time the level was remarkably lower in the trial group(50. 5%vs 74. 5% ,P<0. 05). It is suggested that in instances when radical resection is not possible regional infusion chemotherapy via hepatic artery and portal vein may be given following palliative resection of the primary tumor.