| 脑膜瘤的雌孕激素受体 |
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| 引用本文： | 鲍圣德 王燕复. 脑膜瘤的雌孕激素受体[J]. 中国肿瘤临床, 1994, 21(3): 216-218,T222 |
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| 作者姓名： | 鲍圣德 王燕复 |
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| 作者单位： | 北京医科大学第一医院神经外科，天津医学院附属医院，天津医学院附属医院，天津市计划生育研究所，天津市计划生育研究所 邮编 100034 天津医学院附属医院 天津市300052 神经外科，天津市300052 神经外科，天津市300052 神经外科 |
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| 摘 要： | 本文对３３例脑膜瘤的ＥＲ，ＰＲ作了分析。脑膜瘤性激素受体的阳性率：ＥＲｃ为０，ＥＲｎ为６．１％，ＰＲｃ为１２．１％，ＰＲｎ为６３．３％。多数肿瘤中测不到ＥＲ，且测到者含量变极低。ＰＲ含量明显高于ＥＲ，认为脑膜瘤以ＰＲ占优势。ＰＲ与ＥＲ间无相关关系，ＥＲｎ（ｇ ），ＰＲｎ（＋）者明显多于ＥＲｎ（＋），ＰＲｎ（＋）者，提示脑瘤的ＰＲ可能是一个不依赖于ＥＲ调节的独立系统。本资料为脑膜瘤的激素治疗可能性提
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| 关 键 词： | 脑膜瘤 雌激素 孕激素 受体 |
Estrogen and Progesterone Receptors in Meningiomas |
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| Bao Sheng-De et al. Estrogen and Progesterone Receptors in Meningiomas[J]. Chinese Journal of Clinical Oncology, 1994, 21(3): 216-218,T222 |
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| Authors: | Bao Sheng-De et al |
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| Affiliation: | Bao Sheng-De et al Department of Neurosurgery,Tianjin Medical College Hospital,Tianjin |
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| Abstract: | Estrogen receptor (ER)and progesterone receptor (PgR) were assayed in 33 specimens of menin-gioma. The positive rates of cytoplasmic ER(ERc), ERn (nucleus ER),PgRc and PgRn were 0,6. 1%,12.1% and 63. 3% respectively. Most of the tumor samples had no detectable ER. Even in a small number of ER positive samples,the level of ER measured was low. The level of PgR was significantly higher than ER. It seems that PgR is predominant in meningioma. Since PgR showed no association with ER and the samples with ERn ( - ) , PgRn ( ) were much more frequent than the tumors with ERn( ) ,PgRn( ) ,it is suggested that PgR is probably an independent system which is not regulated via estrogen-ER. The existence of ER and PgR in meningiomas provides theoretical potential for hormonal therapy of menigniomas. |
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| Keywords: | Meningiomas Estrogen receptor (ER) Progesterone receptor (PgR) |
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