| 亲和组化法对消化道肿瘤雌,孕激素受体的细胞学研究 |
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| 引用本文： | 戴洁,薄爱华.亲和组化法对消化道肿瘤雌,孕激素受体的细胞学研究[J].中国肿瘤临床,1994,21(5):349-351,T000. |
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| 作者姓名： | 戴洁 薄爱华 |
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| 作者单位： | 张家口医学院 张家口市075029 |
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| 摘 要： | 本文采用Ｅ２－ＨＲＰ、Ｐｇ－ＨＲＰ亲和组化法检测１００例消化道肿瘤的ＥＲ，ＰｇＲｏ结果表明：ＥＲ阳性者３７例（３７％），ＰｇＲ阳性者２２例（２２％），肿瘤的分化程度与ＥＲ，ＰｇＲ水平呈正相关。管状腺癌阳性率最高，胃肿瘤ＥＲ阳性率明显低于结，直肠癌，性别，年龄，临床分期与ＥＲ，ＰｇＲ主要存在于细胞核内与常染色质及核仁关系密切。
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| 关 键 词： | 雌激素 孕激素 受体 消化系肿瘤 |
Study of Estrogen and Progesterone Receptors in the Tumors of Digestive Tract with Affinity Histochemical Method |
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| Dai Jie et alZhang jiakou Medical College,Zhang jiakou.Study of Estrogen and Progesterone Receptors in the Tumors of Digestive Tract with Affinity Histochemical Method[J].Chinese Journal of Clinical Oncology,1994,21(5):349-351,T000. |
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| Authors: | Dai Jie Zhang jiakou Medical College Zhang jiakou |
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| Abstract: | Estrogen and progesterone receptors were determined with E2-HRP and Pg-HRP in 100 tumors ofthe digestive tract. The results showed that ER and PgR were found positive in 37(37% of cases)and 22(22% of cases) respectively. The cellular differentiation was positively correlated with the level of ER and PgR. The positive rate of ER was the highest in tubular adenocarcinoma. ER and PgR levels were significantly lower in stomach tumors as compared with colorectal tumors. Frequency of positivity in cells was- not related with sex, age and clinical stage. Observation with immunoelectron microscope showed that ER and PgR were found in the nucleus and closely associated with autochromatin and nucleolus. |
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| Keywords: | Tumor Digestive tract Estrogen receptor Progesterone receptor Affinity histochemical method |
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