| 恶性淋巴瘤患者输注／移植人胚胸腺细胞后T淋巴细胞亚群的分布 |
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| 引用本文： | 钱林法 钟雪帆. 恶性淋巴瘤患者输注／移植人胚胸腺细胞后T淋巴细胞亚群的分布[J]. 中国肿瘤临床, 1994, 21(1): 17-20 |
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| 作者姓名： | 钱林法 钟雪帆 |
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| 作者单位： | 河南省肿瘤研究所，河南省肿瘤研究所，河南省肿瘤研究所，河南省肿瘤研究所，河南省肿瘤研究所，无锡市临床医学实验研究所，河南中医学院 郑州市450003，郑州市450003，郑州市450003，郑州市450003，郑州市450003，函授生 |
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| 摘 要： | 本文采用OKT系列McAb检测了15例恶性淋巴瘤患者输注人胚胸腺细胞前后的T淋巴细胞亚群的分布.结果表明输注后,OKT_3~ ,OKT_4~ 细胞较前有显著提高,OKT_8~ 细胞显著降低,OKT_4~ /OKT_8~ 比值亦有显著提高,小淋巴细胞总数变化与OKT_3~ 亚群的变化相一致,IgG也较前有所增加.这些变化,输注1个半月后较半月者更为显著.经肿瘤治疗,骨髓当处受抑状态,可将输注视为细胞移植范畴.胸腺内的早期T细胞可重组在受体胸腺组织内,实现免疫重建,纠正与Ts细胞分化有关的免疫抑制.
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| 关 键 词： | 恶性淋巴瘤 T细胞亚群 人胚胸腺细胞移植(FTT) 免疫受抑 重组胸腺细胞亚群 |
T-cell Subsets in Patients with Malignant Lymphoma after Transfusion of Fetal Thymocytes |
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| Qian Lin-Fa et al Henan Provincial Tunor Institute,Zhengzhou. T-cell Subsets in Patients with Malignant Lymphoma after Transfusion of Fetal Thymocytes[J]. Chinese Journal of Clinical Oncology, 1994, 21(1): 17-20 |
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| Authors: | Qian Lin-Fa et al Henan Provincial Tunor Institute Zhengzhou |
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| Abstract: | Monoclonal antibodies of OKT series were used in the assessment of T-cell subsets in 15 patients with malignant lymphoma before and after human fetal thymocytes were transfused. The result showed that OKT3 , OKT4 cells increased and OKT8 cells declined markedly while the ratio of OKT4 /OKT8 posttransfusion was significantly higher than that of antetransfusion and that the total number of small lymphocytes remained unchanged. The IgG content increased a little bit following transfusion. All the above changes became more significant one and half months afterwards than they were half a month aftertransfusion. . |
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| Keywords: | Malignant lymphoma T-cel! subset Fetal thymocytes Transfusion |
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