| 靶向微小RNA的病毒感染疾病治疗新策略 |
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| 引用本文： | 马永洁,周喆,王升启.靶向微小RNA的病毒感染疾病治疗新策略[J].国际药学研究杂志,2009,36(2):86-89. |
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| 作者姓名： | 马永洁 周喆 王升启 |
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| 作者单位： | 军事医学科学院放射与辐射研究所,北京,100850 |
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| 摘 要： | 微小RNA(microRNA,miRNA)是真核生物细胞的一类长度约为19～25个核苷酸的非编码小RNA，在生物体发育和基因表达过程发挥重要的调控作用。miRNA分子通过与靶mRNA的互补配对，在转录后水平上对基因的表达进行负调控。近来研究表明miRNA在病毒感染宿主过程中发挥重要作用。通过设计抗miRNA反义寡核苷酸促进或阻断特定miRNA的表达可以实现抑制病毒复制的目标。本文综述了抗miRNA反义寡核苷酸研究现状和面临的挑战。
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| 关 键 词： | 微小RNA 寡核苷酸类 反义 抗病毒药 |
| 收稿时间： | 2008-10-30 |
New therapeutic strategy targeting microRNAs for virally induced diseases |
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| MA Yong-jie,ZHOU Zhe,WANG Sheng-qi.New therapeutic strategy targeting microRNAs for virally induced diseases[J].Foreign Medical Sciences(Section of Pharmarcy),2009,36(2):86-89. |
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| Authors: | MA Yong-jie ZHOU Zhe WANG Sheng-qi |
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| Institution: | （Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing, 100850, China） |
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| Abstract: | MicroRNAs (miRNAs) are endogenous 19-25 nucleotide RNAs that play important roles in the regulation of development and gene expression. MiRNAs negatively regulate target mRNAs by binding with imperfect complementarity in their 3′-untranslated regions. Recent studies suggest that miRNAs have profound influence and play a complex role in regulating host-virus interactions.We can design sequence-specific anti-miRNA oligonucleotides (AMO) to inhibit virus replication. In this review, we summarize in brief advance and challenge of AMO as antiviral drug development. |
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| Keywords: | microRNA oligonucleotides antisense antiviral agents |
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