Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid |
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| Authors: | Tomita N Kanamori H Fujita H Maruta A Naitoh A Nakamura S Ota Y Nozue N Kihara M Ishigatsubo Y |
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| Institution: | Department of Hematology , Fujieda Municipal General Hospital, Shizuoka, 426-8677, Japan. cavalier@ch-yamate.dienet.com |
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| Abstract: | We report the first case of granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid (ATRA) in a patient with acute promyelocytic leukemia (APL). Acute renal failure during treatment with ATRA has been previously reported as a part of an ATRA syndrome or a thrombotic complication of a hypercoagulable state. This case indicates an alternative mechanism of acute renal failure occurring during ATRA therapy. |
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