| 原发性胆汁性肝硬化的临床研究 |
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| 引用本文： | 王兆彬.原发性胆汁性肝硬化的临床研究[J].中外医疗,2012,31(33):92+94-92,94. |
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| 作者姓名： | 王兆彬 |
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| 作者单位： | 山东省威海市威海卫人民医院消化内科 |
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| 摘 要： | 目的分析临床资料,总结原发性胆汁性肝硬化（PBC）患者的临床表现和病理特征。方法对86例PBC患者的临床资料进行回顾性分析。结果 86例PBC患者临床主要表现为黄疸（60%）,尿黄（51%）,腹胀（30%）,皮肤瘙痒（20%）。患者ALP和GGT水平明显升高,分别为（239.6±139.2）U/L和（253.6±225.1）U/L,ALT和AST轻度升高,平均为（197.2±284.9）U/L和（167.9±174.1）U/L。48%的患者IgM水平明显升高,平均为（3.6±2.4）g/L,67%的AMA-M2阳性和61%的ANA阳性。结论 ALP、GGT、AMA-M2和ANA有利于PBC的早期诊断,这样有利于延缓病情和改善预后。
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| 关 键 词： | 原发性胆汁肝硬化 临床表现 治疗 |
Analysis of primary billiary cirrhosis |
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| WANG Zhaobin.Analysis of primary billiary cirrhosis[J].China Foreign Medical Treatment,2012,31(33):92+94-92,94. |
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| Authors: | WANG Zhaobin |
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| Institution: | WANG Zhaobin Department of Gastronentirology,Weihaiwei People’s Hospital,Weihai 264200,China |
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| Abstract: | Objective To analyze the features of clinic,biochemistry,immunology and pathology in primary biliary cirrhosis.Methods General status,clinical manifestations and of 86 patients with PBC were reviewed.Results The most frequently complained symptoms were jaundice（60%）,fatigue（54%）,ascites（30%）andpruitus（20%）.ALP and GGT levels were remarkably elevated in majority patients（239.6 ±139.2）U/L and（253.6 ±225.1）U/L,whereas ALT and AST levels were mildly to moderately elevated（197.2±284.9）U/L and（167.9±174.1）U/L.34.2 tLmol / L.41 patients（48%） had elevated serum IgM and 58 patients（67%） were antimitochondrial anti-body（AMA）/AMA-M2 positive.Conclusion Elevated serum ALP and GGT levels together with positive AMA/ AMA-M2 can help to diagnose. |
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| Keywords: | Primary biliary cirrhosis Clinical research Treatment |
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