| 胃癌及癌前病变原位DNA含量与核仁组成区嗜银蛋白定量分析的相关性研究 |
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| 引用本文： | 林一帆 陈希陶. 胃癌及癌前病变原位DNA含量与核仁组成区嗜银蛋白定量分析的相关性研究[J]. 癌症, 1993, 12(1): 26-29 |
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| 作者姓名： | 林一帆 陈希陶 |
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| 作者单位： | 第四军医大学西京医院消化内科，第四军医大学西京医院消化内科，第四军医大学西京医院消化内科，第四军医大学西京医院消化内科，第四军医大学西京医院消化内科，第四军医大学西京医院消化内科 西安 710032，西安 710032，西安 710032，西安 710032，西安 710032，西安 710032 |
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| 摘 要： | 本文用图像分析的方法对正常胃粘膜、轻、中、重度异型增生、管状腺癌及低分化腺癌共30例石蜡切片标本的细胞核仁组成区嗜银蛋白(AgNOR)和细胞核DNA含量进行了定量检测,并进行了两者的相关性研究。结果显示AgNOR颗粒数量及DNA含量均随病变程度加重而增加,AgNOR数量与DNA含量、超二倍体及超四倍体细胞百分数、DNA直方图倍体类型之间有明显的相关性(r=0.8811,0.7288,0.8606,0.8793);提示AgNOR数量与DNA含量的变化对胃癌前病变的判断与研究具有相近的意义。与细胞核DNA含量检测相比,AgNOR计数分析具有染色简便,易于推广的优点,是胃癌及癌前病变研究中一项新的、实用的参考指标。
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| 关 键 词： | 核仁组成区 胃肿瘤 嗜银蛋白 |
CORRELATION BETWEEN DNA CONTENT AND NUCLEOLAR ORGANIZER REGION SITES IN GASTRIC CANCER AND DYSPLASIA |
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| LIN Yi-Fan CHEN Xi-Tao HU Jia-Iu DING Hua-Ye ZHU Ming-HuaZHANG Xue-Yong. CORRELATION BETWEEN DNA CONTENT AND NUCLEOLAR ORGANIZER REGION SITES IN GASTRIC CANCER AND DYSPLASIA[J]. Chinese journal of cancer, 1993, 12(1): 26-29 |
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| Authors: | LIN Yi-Fan CHEN Xi-Tao HU Jia-Iu DING Hua-Ye ZHU Ming-HuaZHANG Xue-Yong |
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| Abstract: | The nucleolar organizer region associated protein (AgNOR) andthe DNA content were measured by image analysis technique in paraffin sections of 30 cases with normal mucosa, (mild, moderate or severe dysplasia), adenocarcinoma or poorly differentiated adenocarcinoma. The results of study showed that AgNOR sites, DNA content, the percentage of >2c and >4c cells incerased with severity of transfro-mation from dysplasia to carinoma. There was a very good linear correlation between the mean numbers of AgNOR sites per nucleus and the assessment of gastric cancer and dysplasia. |
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| Keywords: | Dysplasia Nucleolar orgsnizer region DNA content Image analysis technique |
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