山苍子油平喘与抗过敏药理研究

本文报告山苍子油的平喘与抗过敏药理研究结果。山苍子油能松弛豚鼠离体气管平滑肌,增加豚鼠离体肺灌流量。对豚鼠因吸入致痉剂所致药物性哮喘有明显保护作用。对大鼠被动皮肤过敏反应(PCA)有抑制作用。能保护豚鼠过敏性休克和抑制豚鼠离体回肠过敏性收缩。对慢反应物质(SRS-A)引致豚鼠离体回肠收缩有阻断和拮抗作用。山苍子油上述药理作用为其对慢性支气管炎的良好疗效提供了依据。

PHARMACOLOGICAL STUDIES ON ANTI-ASTHMATIC AND ANTI-ANAPHYLACTIC ACTIVITIES OF THE ESSENTIAL OIL OF LITSEA CUBEBA(LOUR.) PERS.

The bronchodilating and anti-anaphylactic activity of the essential oil extracted from the fresh fruits of Litsea cubeba (Lour.) Pers. was investigated in laboratory. The oil (90 μl/ml) was found to produce a relaxing effect on guinea-pig tracheal smooth muscle with or without being contracted by histamine or acetylcholine in vitro and to increase(0.1 μl/ml) the perfusion rate of isolated lung preparation of guineapig from 21.2±2.8 to 38.3±6.3 ml/min(P<0.025). The oil, administrated orally, intraperitoneally or by inhalation showed prominent protective effect against bronchial asthma induced. by inhalation of bronchoconstrictors in conscious guinea-pigs. The oil was shown to inhibit the passive cutaneous anaphylaxis (PCA) reaction in rats, and the inhibition obtained was 47.4±4.5% that of the control. In guineapigs sensitized with egg albumin, significant inhibitory effects both on anaphylactic shock induced by inhalation of antigen aerosol in vivo and on spasmodic contraction of guinea-pig ileum induced by antigen challenge in vitro were observed. Besides, the oil (30 μl/ml) was found to block and counteract the contractive activity of SRS-A on the isolated guinea pig ileum.