骨关节病患者股骨距区域骨密度测量分析

目的通过骨形态计量学来探讨骨密度与人工关节置换后远期临床结果之间的关系，从而考虑通过远端涂层的假体设计来增强假体稳定性。方法采用组织计量学方法，将235例因患骨关节病在St．Michael’s医院(Toronto，Canada)行全髋关节置换而切除的股骨头分为5组。对其股骨距区骨密度进行了测量。结果不同组股骨距哈弗氏管含量均比正常值高(正常：3％)。骨性关节炎(OA)组与类风湿关节炎(RA)组、骨折组的哈弗氏管含量比较差异无显著性意义；OA组与股骨头无菌坏死(ON)组的哈弗氏管含量比较差异有显著性意义。结论本研究同样采用组织形态计量学方法，测量结果均高于正常值，表明骨关节病患者股骨距骨密度是降低的。考虑通过远端涂层的假体设计来增强假体稳定性，来达到良好的固定及增加假体的寿命。

Bone Mineral Density Measurement and Analysis of Femoral Cortex in the Patients with Osteoarthritis

Objective To discuss the relationship between the bone mineral density of femoral cortex and the long-term result of prosthetic replacement of joint.Methods Two hundred and thirty five femoral heads removed by joint replacement surgery were divided into 5 groups.The bone mineral density of the cortex was examined by computer-assisted system.Results The density of Haversian canals in 5 groups were all higher than that of the normal value.No significant difference was observed between OA,RA and fracture groups (P>0.05).The density of Haversian canals in OA group was significantly higher than ON group.Conclusion The bone mineral density of femoral cortex in the patients with osteoarthritis was decreased.The full coating of the prosthesis design should be considered to improve the implant stability and achieve good long-term result.